Reaction Details |
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Target | Thromboxane A2 receptor |
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Ligand | BDBM50037772 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_209593 (CHEMBL814728) |
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IC50 | 70.0±n/a nM |
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Citation | Cozzi, P; Giordani, A; Menichincheri, M; Pillan, A; Pinciroli, V; Rossi, A; Tonani, R; Volpi, D; Tamburin, M; Ferrario, R Agents combining thromboxane receptor antagonism with thromboxane synthase inhibition: [[[2-(1H-imidazol-1-yl)ethylidene]amino]oxy]alkanoic acids. J Med Chem37:3588-604 (1994) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Thromboxane A2 receptor |
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Name: | Thromboxane A2 receptor |
Synonyms: | Prostanoid TP receptor | TA2R_HUMAN | TBXA2R | TXA2-R | Thromboxane | Thromboxane A2 receptor | Thromboxane Beta |
Type: | Enyzme |
Mol. Mass.: | 37445.28 |
Organism: | Homo sapiens (Human) |
Description: | P21731 |
Residue: | 343 |
Sequence: | MWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQGGSHTR
SSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGCRLCRFMGVVMIFFGLSPL
LLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALALGLLPLLGVGRYTVQYPG
SWCFLTLGAESGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGQEAAQQRPRDSE
VEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLRVATWN
QILDPWVYILFRRAVLRRLQPRLSTRPRSLSLQPQLTQRSGLQ
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BDBM50037772 |
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n/a |
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Name | BDBM50037772 |
Synonyms: | 5-[1-Cyclohexyl-2-imidazol-1-yl-3-(4-methoxy-phenyl)-prop-(E)-ylideneaminooxy]-pentanoic acid | CHEMBL331218 |
Type | Small organic molecule |
Emp. Form. | C24H33N3O4 |
Mol. Mass. | 427.5365 |
SMILES | COc1ccc(CC(\C(=N\OCCCCC(O)=O)C2CCCCC2)n2ccnc2)cc1 |
Structure |
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