| Reaction Details |
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 | Report a problem with these data |
| Target | Phosphodiesterase |
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| Ligand | BDBM50038975 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_155976 (CHEMBL762029) |
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| IC50 | >100000±n/a nM |
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| Citation |  Takase, Y; Saeki, T; Watanabe, N; Adachi, H; Souda, S; Saito, I Cyclic GMP phosphodiesterase inhibitors. 2. Requirement of 6-substitution of quinazoline derivatives for potent and selective inhibitory activity. J Med Chem37:2106-11 (1994) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Phosphodiesterase |
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| Name: | Phosphodiesterase |
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| Synonyms: | Phosphodiesterase 3A |
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| Type: | PROTEIN |
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| Mol. Mass.: | 108833.33 |
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| Organism: | Sus scrofa |
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| Description: | ChEMBL_155977 |
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| Residue: | 985 |
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| Sequence: | MGLYLLRAGVRLPLAVALLAACCGGEALVQIGLGVGEDHLLSLPAATWLVLRLRLGVLMI
ALTSAVRTVSLISLERFKVAWRPYLAYLAGVLGILLARYVEQILPQSAGAAPREHFGSQL
LAGTKEDIPEFKRRRRSSSVVSAEMSGCSSKSHRRTSLPCIPREQLMGHSEWDHKRGPRG
SQSSGTSITVDIAVMGEAHGLITDLLADPSLPPNVCTSLRAVSNLLSTQLTFQAIHKPRV
NPAVSFSENYTCSDSEESAEKDKLAIPKRLRRSLPPGLLRRVSSTWTTTTSATGLPTLEP
SPVRRDRSASIKLHEAPSSSAINPDSWKNPVMMTLTKSRSFTSSYAVSASNHVKAKKQSR
PGSLVKISPLSSPCSSALQGTPASSPVSKISTVQFPEPADATAKQGLSSHKALTYTQSAP
DLSPHILTPPVICSSCGRPYSQGNPADGPLERSGPAIQAQSRTDDTAQVTSDYETNNNSD
SSDIVQNEDETECSREPLRKASACSAYTPDTMMFLDKPILAPEPLVMDNLDSIMEHLNTW
NFPIFDLVEKIGRKCGRILSQVSYRLFEDMGLFEAFKIPIREFMNYFHALEIGYREIPYH
NRIHATDVLHAVWYLTTQPIPGLSTVINDHGSTSDSDSDSGFTHGHMGYVFSKMYNVPDD
KYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAA
AWNLFMSRTEYNFLVNLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNAKVNDEVGIDW
TNENDRLLVCQMCIKLADINGPAKCKELHLQWTEGIVNEFYEQGDEEASLGLPISPFMDR
SAPQLANLQESFISHIVGPLCNSYDSAGLMPGKWVEDSDESGDTDDPEEEEAPKEEETCE
NNDSPRKKTFKRRKIYCQITQHLLQNHKMWKKVIEEEQRLAGIESQSLDQAPQQHSSEQI
QAIKEEDEDKGKPRGEETPTPKPNQ
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| BDBM50038975 |
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| n/a |
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| Name | BDBM50038975 |
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| Synonyms: | Benzo[1,3]dioxol-5-ylmethyl-(6-methylsulfanyl-quinazolin-4-yl)-amine | CHEMBL304927 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H15N3O2S |
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| Mol. Mass. | 325.385 |
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| SMILES | CSc1ccc2ncnc(NCc3ccc4OCOc4c3)c2c1 |
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| Structure | 
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