| Reaction Details |
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 | Report a problem with these data |
| Target | Prostaglandin E2 receptor EP1 subtype |
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| Ligand | BDBM50493973 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_989440 (CHEMBL2443717) |
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| IC50 | 580±n/a nM |
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| Citation |  Atobe, M; Naganuma, K; Kawanishi, M; Morimoto, A; Kasahara, K; Ohashi, S; Suzuki, H; Hayashi, T; Miyoshi, S Hit-to-lead optimization of 2-(1H-pyrazol-1-yl)-thiazole derivatives as a novel class of EP1 receptor antagonists. Bioorg Med Chem Lett23:6064-7 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prostaglandin E2 receptor EP1 subtype |
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| Name: | Prostaglandin E2 receptor EP1 subtype |
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| Synonyms: | PE2R1_HUMAN | PGE receptor, EP1 subtype | PTGER1 | Prostaglandin E2 receptor | Prostaglandin E2 receptor EP1 subtype | Prostaglandin E2 receptor EP1 subtype (EP1) | Prostanoid EP1 receptor |
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| Type: | Enzyme |
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| Mol. Mass.: | 41834.57 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P34995 |
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| Residue: | 402 |
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| Sequence: | MSPCGPLNLSLAGEATTCAAPWVPNTSAVPPSGASPALPIFSMTLGAVSNLLALALLAQA
AGRLRRRRSAATFLLFVASLLATDLAGHVIPGALVLRLYTAGRAPAGGACHFLGGCMVFF
GLCPLLLGCGMAVERCVGVTRPLLHAARVSVARARLALAAVAAVALAVALLPLARVGRYE
LQYPGTWCFIGLGPPGGWRQALLAGLFASLGLVALLAALVCNTLSGLALLRARWRRRSRR
PPPASGPDSRRRWGAHGPRSASASSASSIASASTFFGGSRSSGSARRARAHDVEMVGQLV
GIMVVSCICWSPMLVLVALAVGGWSSTSLQRPLFLAVRLASWNQILDPWVYILLRQAVLR
QLLRLLPPRAGAKGGPAGLGLTPSAWEASSLRSSRHSGLSHF
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| BDBM50493973 |
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| n/a |
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| Name | BDBM50493973 |
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| Synonyms: | CHEMBL2442489 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H8F3N3O3S |
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| Mol. Mass. | 355.292 |
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| SMILES | OC(=O)c1csc(n1)-n1nc(cc1C(F)(F)F)-c1cccc(O)c1 |
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| Structure | 
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