Found 134 hits with Last Name = 'miyoshi' and Initial = 's' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human)) | BDBM50444438
(CHEMBL2442495)Show SMILES Cc1c(nn(-c2nc(cs2)C(O)=O)c1-c1ccccc1)-c1ccccc1 Show InChI InChI=1S/C20H15N3O2S/c1-13-17(14-8-4-2-5-9-14)22-23(18(13)15-10-6-3-7-11-15)20-21-16(12-26-20)19(24)25/h2-12H,1H3,(H,24,25) | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 290 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description
Binding affinity to human EP1 receptor |
Bioorg Med Chem Lett 23: 6064-7 (2013)
Article DOI: 10.1016/j.bmcl.2013.09.032
BindingDB Entry DOI: 10.7270/Q2959MJ5 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human)) | BDBM50493969
(CHEMBL2442490)Show SMILES OC(=O)c1csc(n1)-n1nc(cc1C(F)(F)F)-c1ccccc1O Show InChI InChI=1S/C14H8F3N3O3S/c15-14(16,17)11-5-8(7-3-1-2-4-10(7)21)19-20(11)13-18-9(6-24-13)12(22)23/h1-6,21H,(H,22,23) | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
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| Purchase
PC cid
PC sid
UniChem
| Article
PubMed
| 530 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description
Binding affinity to human EP1 receptor |
Bioorg Med Chem Lett 23: 6064-7 (2013)
Article DOI: 10.1016/j.bmcl.2013.09.032
BindingDB Entry DOI: 10.7270/Q2959MJ5 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Homo sapiens (Human)) | BDBM50493969
(CHEMBL2442490)Show SMILES OC(=O)c1csc(n1)-n1nc(cc1C(F)(F)F)-c1ccccc1O Show InChI InChI=1S/C14H8F3N3O3S/c15-14(16,17)11-5-8(7-3-1-2-4-10(7)21)19-20(11)13-18-9(6-24-13)12(22)23/h1-6,21H,(H,22,23) | PDB
Reactome pathway
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PC cid
PC sid
UniChem
| Article
PubMed
| >2.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description
Binding affinity to human EP4 receptor |
Bioorg Med Chem Lett 23: 6064-7 (2013)
Article DOI: 10.1016/j.bmcl.2013.09.032
BindingDB Entry DOI: 10.7270/Q2959MJ5 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Homo sapiens (Human)) | BDBM50444438
(CHEMBL2442495)Show SMILES Cc1c(nn(-c2nc(cs2)C(O)=O)c1-c1ccccc1)-c1ccccc1 Show InChI InChI=1S/C20H15N3O2S/c1-13-17(14-8-4-2-5-9-14)22-23(18(13)15-10-6-3-7-11-15)20-21-16(12-26-20)19(24)25/h2-12H,1H3,(H,24,25) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >2.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description
Binding affinity to human EP4 receptor |
Bioorg Med Chem Lett 23: 6064-7 (2013)
Article DOI: 10.1016/j.bmcl.2013.09.032
BindingDB Entry DOI: 10.7270/Q2959MJ5 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Homo sapiens (Human)) | BDBM50493968
(CHEMBL2442485)Show SMILES COc1ccc(cc1)-c1cc(nn1-c1nc(cs1)C(O)=O)C(F)(F)F Show InChI InChI=1S/C15H10F3N3O3S/c1-24-9-4-2-8(3-5-9)11-6-12(15(16,17)18)20-21(11)14-19-10(7-25-14)13(22)23/h2-7H,1H3,(H,22,23) | PDB
Reactome pathway
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PC sid
UniChem
| Article
PubMed
| >2.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description
Binding affinity to human EP4 receptor |
Bioorg Med Chem Lett 23: 6064-7 (2013)
Article DOI: 10.1016/j.bmcl.2013.09.032
BindingDB Entry DOI: 10.7270/Q2959MJ5 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50444438
(CHEMBL2442495)Show SMILES Cc1c(nn(-c2nc(cs2)C(O)=O)c1-c1ccccc1)-c1ccccc1 Show InChI InChI=1S/C20H15N3O2S/c1-13-17(14-8-4-2-5-9-14)22-23(18(13)15-10-6-3-7-11-15)20-21-16(12-26-20)19(24)25/h2-12H,1H3,(H,24,25) | PDB
KEGG
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antibodypedia
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description
Binding affinity to human EP3 receptor |
Bioorg Med Chem Lett 23: 6064-7 (2013)
Article DOI: 10.1016/j.bmcl.2013.09.032
BindingDB Entry DOI: 10.7270/Q2959MJ5 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50493968
(CHEMBL2442485)Show SMILES COc1ccc(cc1)-c1cc(nn1-c1nc(cs1)C(O)=O)C(F)(F)F Show InChI InChI=1S/C15H10F3N3O3S/c1-24-9-4-2-8(3-5-9)11-6-12(15(16,17)18)20-21(11)14-19-10(7-25-14)13(22)23/h2-7H,1H3,(H,22,23) | PDB
KEGG
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| Purchase
PC cid
PC sid
UniChem
| Article
PubMed
| >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description
Binding affinity to human EP3 receptor |
Bioorg Med Chem Lett 23: 6064-7 (2013)
Article DOI: 10.1016/j.bmcl.2013.09.032
BindingDB Entry DOI: 10.7270/Q2959MJ5 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50493969
(CHEMBL2442490)Show SMILES OC(=O)c1csc(n1)-n1nc(cc1C(F)(F)F)-c1ccccc1O Show InChI InChI=1S/C14H8F3N3O3S/c15-14(16,17)11-5-8(7-3-1-2-4-10(7)21)19-20(11)13-18-9(6-24-13)12(22)23/h1-6,21H,(H,22,23) | PDB
KEGG
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antibodypedia
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| Purchase
PC cid
PC sid
UniChem
| Article
PubMed
| >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description
Binding affinity to human EP3 receptor |
Bioorg Med Chem Lett 23: 6064-7 (2013)
Article DOI: 10.1016/j.bmcl.2013.09.032
BindingDB Entry DOI: 10.7270/Q2959MJ5 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM50444438
(CHEMBL2442495)Show SMILES Cc1c(nn(-c2nc(cs2)C(O)=O)c1-c1ccccc1)-c1ccccc1 Show InChI InChI=1S/C20H15N3O2S/c1-13-17(14-8-4-2-5-9-14)22-23(18(13)15-10-6-3-7-11-15)20-21-16(12-26-20)19(24)25/h2-12H,1H3,(H,24,25) | PDB
Reactome pathway
KEGG
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antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >8.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description
Binding affinity to human EP2 receptor |
Bioorg Med Chem Lett 23: 6064-7 (2013)
Article DOI: 10.1016/j.bmcl.2013.09.032
BindingDB Entry DOI: 10.7270/Q2959MJ5 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM50493969
(CHEMBL2442490)Show SMILES OC(=O)c1csc(n1)-n1nc(cc1C(F)(F)F)-c1ccccc1O Show InChI InChI=1S/C14H8F3N3O3S/c15-14(16,17)11-5-8(7-3-1-2-4-10(7)21)19-20(11)13-18-9(6-24-13)12(22)23/h1-6,21H,(H,22,23) | PDB
Reactome pathway
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PC cid
PC sid
UniChem
| Article
PubMed
| >8.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description
Binding affinity to human EP2 receptor |
Bioorg Med Chem Lett 23: 6064-7 (2013)
Article DOI: 10.1016/j.bmcl.2013.09.032
BindingDB Entry DOI: 10.7270/Q2959MJ5 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM50493968
(CHEMBL2442485)Show SMILES COc1ccc(cc1)-c1cc(nn1-c1nc(cs1)C(O)=O)C(F)(F)F Show InChI InChI=1S/C15H10F3N3O3S/c1-24-9-4-2-8(3-5-9)11-6-12(15(16,17)18)20-21(11)14-19-10(7-25-14)13(22)23/h2-7H,1H3,(H,22,23) | PDB
Reactome pathway
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| Purchase
PC cid
PC sid
UniChem
| Article
PubMed
| >8.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description
Binding affinity to human EP2 receptor |
Bioorg Med Chem Lett 23: 6064-7 (2013)
Article DOI: 10.1016/j.bmcl.2013.09.032
BindingDB Entry DOI: 10.7270/Q2959MJ5 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human)) | BDBM50493968
(CHEMBL2442485)Show SMILES COc1ccc(cc1)-c1cc(nn1-c1nc(cs1)C(O)=O)C(F)(F)F Show InChI InChI=1S/C15H10F3N3O3S/c1-24-9-4-2-8(3-5-9)11-6-12(15(16,17)18)20-21(11)14-19-10(7-25-14)13(22)23/h2-7H,1H3,(H,22,23) | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
PC cid
PC sid
UniChem
| Article
PubMed
| 8.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description
Binding affinity to human EP1 receptor |
Bioorg Med Chem Lett 23: 6064-7 (2013)
Article DOI: 10.1016/j.bmcl.2013.09.032
BindingDB Entry DOI: 10.7270/Q2959MJ5 |
More data for this
Ligand-Target Pair | |
Bromodomain-containing protein 4/Histone H4
(Homo sapiens (Human)) | BDBM179292
(US9125915, compound 17)Show SMILES CONC(=O)C[C@@H]1N=C(c2c(C)c(C)sc2-n2c(C)nnc12)c1ccc(Cl)cc1 |r,c:7| Show InChI InChI=1S/C20H20ClN5O2S/c1-10-11(2)29-20-17(10)18(13-5-7-14(21)8-6-13)22-15(9-16(27)25-28-4)19-24-23-12(3)26(19)20/h5-8,15H,9H2,1-4H3,(H,25,27)/t15-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 12.8 | n/a | n/a | n/a | n/a | n/a | 25 |
Mitsubishi Tanabe Pharma Corporation
US Patent
| Assay Description
An expression vector containing cDNA of BRD2, 3 and 4 added with Flag-tag was transfected to CHO cell, and a cell lysate was prepared 24 hr later. Bi... |
US Patent US9125915 (2015)
BindingDB Entry DOI: 10.7270/Q26972BJ |
More data for this
Ligand-Target Pair | |
Bromodomain-containing protein 4/Histone H4
(Homo sapiens (Human)) | BDBM179288
(US9125915, compound 13)Show SMILES CNC(=O)CC1N=C(c2c(C)c(C)sc2-n2c(C)nnc12)c1ccc(Cl)cc1 |c:6| Show InChI InChI=1S/C20H20ClN5OS/c1-10-11(2)28-20-17(10)18(13-5-7-14(21)8-6-13)23-15(9-16(27)22-4)19-25-24-12(3)26(19)20/h5-8,15H,9H2,1-4H3,(H,22,27) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 17.3 | n/a | n/a | n/a | n/a | n/a | 25 |
Mitsubishi Tanabe Pharma Corporation
US Patent
| Assay Description
An expression vector containing cDNA of BRD2, 3 and 4 added with Flag-tag was transfected to CHO cell, and a cell lysate was prepared 24 hr later. Bi... |
US Patent US9125915 (2015)
BindingDB Entry DOI: 10.7270/Q26972BJ |
More data for this
Ligand-Target Pair | |
Bromodomain-containing protein 4/Histone H4
(Homo sapiens (Human)) | BDBM179283
(US9125915, compound 6)Show SMILES COC(=O)C[C@@H]1N=C(c2c(C)c(C)sc2-n2c(C)nnc12)c1ccc(Cl)cc1 |r,c:6| Show InChI InChI=1S/C20H19ClN4O2S/c1-10-11(2)28-20-17(10)18(13-5-7-14(21)8-6-13)22-15(9-16(26)27-4)19-24-23-12(3)25(19)20/h5-8,15H,9H2,1-4H3/t15-/m0/s1 | PDB
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MCE
PC cid
PC sid
PDB
UniChem
Similars
| PDB
US Patent
| n/a | n/a | 18.2 | n/a | n/a | n/a | n/a | n/a | 25 |
Mitsubishi Tanabe Pharma Corporation
US Patent
| Assay Description
An expression vector containing cDNA of BRD2, 3 and 4 added with Flag-tag was transfected to CHO cell, and a cell lysate was prepared 24 hr later. Bi... |
US Patent US9125915 (2015)
BindingDB Entry DOI: 10.7270/Q26972BJ |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Bromodomain-containing protein 4/Histone H4
(Homo sapiens (Human)) | BDBM179289
(US9125915, compound 14)Show SMILES Cc1sc-2c(c1C)C(=NC(CC(=O)NCCO)c1nnc(C)n-21)c1ccc(Cl)cc1 |c:8| Show InChI InChI=1S/C21H22ClN5O2S/c1-11-12(2)30-21-18(11)19(14-4-6-15(22)7-5-14)24-16(10-17(29)23-8-9-28)20-26-25-13(3)27(20)21/h4-7,16,28H,8-10H2,1-3H3,(H,23,29) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | 25 |
Mitsubishi Tanabe Pharma Corporation
US Patent
| Assay Description
An expression vector containing cDNA of BRD2, 3 and 4 added with Flag-tag was transfected to CHO cell, and a cell lysate was prepared 24 hr later. Bi... |
US Patent US9125915 (2015)
BindingDB Entry DOI: 10.7270/Q26972BJ |
More data for this
Ligand-Target Pair | |
Bromodomain-containing protein 4/Histone H4
(Homo sapiens (Human)) | BDBM179277
(US9125915, compound 10)Show SMILES COC(=O)C[C@@H]1N=C(c2c(C)c(C)sc2-n2c(C)nnc12)c1ccc(NC(=O)CCc2ccccc2)cc1 |r,c:6| Show InChI InChI=1S/C29H29N5O3S/c1-17-18(2)38-29-26(17)27(31-23(16-25(36)37-4)28-33-32-19(3)34(28)29)21-11-13-22(14-12-21)30-24(35)15-10-20-8-6-5-7-9-20/h5-9,11-14,23H,10,15-16H2,1-4H3,(H,30,35)/t23-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 47.1 | n/a | n/a | n/a | n/a | n/a | 25 |
Mitsubishi Tanabe Pharma Corporation
US Patent
| Assay Description
An expression vector containing cDNA of BRD2, 3 and 4 added with Flag-tag was transfected to CHO cell, and a cell lysate was prepared 24 hr later. Bi... |
US Patent US9125915 (2015)
BindingDB Entry DOI: 10.7270/Q26972BJ |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human)) | BDBM50444438
(CHEMBL2442495)Show SMILES Cc1c(nn(-c2nc(cs2)C(O)=O)c1-c1ccccc1)-c1ccccc1 Show InChI InChI=1S/C20H15N3O2S/c1-13-17(14-8-4-2-5-9-14)22-23(18(13)15-10-6-3-7-11-15)20-21-16(12-26-20)19(24)25/h2-12H,1H3,(H,24,25) | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description
Antagonist activity at human EP1 receptor by reporter gene assay |
Bioorg Med Chem Lett 23: 6064-7 (2013)
Article DOI: 10.1016/j.bmcl.2013.09.032
BindingDB Entry DOI: 10.7270/Q2959MJ5 |
More data for this
Ligand-Target Pair | |
Bromodomain-containing protein 4/Histone H4
(Homo sapiens (Human)) | BDBM179282
(US9125915, compound 5)Show SMILES COC(=O)C[C@@H]1N=C(c2c(C)c(Cl)sc2-n2c(C)nnc12)c1ccc(Cl)cc1 |r,c:6| Show InChI InChI=1S/C19H16Cl2N4O2S/c1-9-15-16(11-4-6-12(20)7-5-11)22-13(8-14(26)27-3)18-24-23-10(2)25(18)19(15)28-17(9)21/h4-7,13H,8H2,1-3H3/t13-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 54.2 | n/a | n/a | n/a | n/a | n/a | 25 |
Mitsubishi Tanabe Pharma Corporation
US Patent
| Assay Description
An expression vector containing cDNA of BRD2, 3 and 4 added with Flag-tag was transfected to CHO cell, and a cell lysate was prepared 24 hr later. Bi... |
US Patent US9125915 (2015)
BindingDB Entry DOI: 10.7270/Q26972BJ |
More data for this
Ligand-Target Pair | |
Bromodomain-containing protein 4/Histone H4
(Homo sapiens (Human)) | BDBM179280
(US9125915, compound 3)Show SMILES CCOC(=O)C[C@@H]1N=C(c2c(C)c(C)sc2-n2c(C)nnc12)c1ccc(Nc2cccnc2)cc1 |r,c:7| Show InChI InChI=1S/C26H26N6O2S/c1-5-34-22(33)13-21-25-31-30-17(4)32(25)26-23(15(2)16(3)35-26)24(29-21)18-8-10-19(11-9-18)28-20-7-6-12-27-14-20/h6-12,14,21,28H,5,13H2,1-4H3/t21-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 54.9 | n/a | n/a | n/a | n/a | n/a | 25 |
Mitsubishi Tanabe Pharma Corporation
US Patent
| Assay Description
An expression vector containing cDNA of BRD2, 3 and 4 added with Flag-tag was transfected to CHO cell, and a cell lysate was prepared 24 hr later. Bi... |
US Patent US9125915 (2015)
BindingDB Entry DOI: 10.7270/Q26972BJ |
More data for this
Ligand-Target Pair | |
Bromodomain-containing protein 4/Histone H4
(Homo sapiens (Human)) | BDBM179285
(US9125915, compound 9)Show SMILES COC(=O)C[C@@H]1N=C(c2c(C)c(C)sc2-n2c(C)nnc12)c1ccc(NCc2ccccc2)cc1 |r,c:6| Show InChI InChI=1S/C27H27N5O2S/c1-16-17(2)35-27-24(16)25(29-22(14-23(33)34-4)26-31-30-18(3)32(26)27)20-10-12-21(13-11-20)28-15-19-8-6-5-7-9-19/h5-13,22,28H,14-15H2,1-4H3/t22-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
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Similars
| US Patent
| n/a | n/a | 73.6 | n/a | n/a | n/a | n/a | n/a | 25 |
Mitsubishi Tanabe Pharma Corporation
US Patent
| Assay Description
An expression vector containing cDNA of BRD2, 3 and 4 added with Flag-tag was transfected to CHO cell, and a cell lysate was prepared 24 hr later. Bi... |
US Patent US9125915 (2015)
BindingDB Entry DOI: 10.7270/Q26972BJ |
More data for this
Ligand-Target Pair | |
Bromodomain-containing protein 4/Histone H4
(Homo sapiens (Human)) | BDBM179281
(US9125915, compound 4)Show SMILES COC(=O)C[C@@H]1N=C(c2c(C)c(CO)sc2-n2c(C)nnc12)c1ccc(Nc2c(F)cc(F)cc2F)cc1 |r,c:6| Show InChI InChI=1S/C26H22F3N5O3S/c1-12-20(11-35)38-26-22(12)23(31-19(10-21(36)37-3)25-33-32-13(2)34(25)26)14-4-6-16(7-5-14)30-24-17(28)8-15(27)9-18(24)29/h4-9,19,30,35H,10-11H2,1-3H3/t19-/m0/s1 | PDB
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| n/a | n/a | 77.2 | n/a | n/a | n/a | n/a | n/a | 25 |
Mitsubishi Tanabe Pharma Corporation
US Patent
| Assay Description
An expression vector containing cDNA of BRD2, 3 and 4 added with Flag-tag was transfected to CHO cell, and a cell lysate was prepared 24 hr later. Bi... |
US Patent US9125915 (2015)
BindingDB Entry DOI: 10.7270/Q26972BJ |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human)) | BDBM50493974
(CHEMBL2442494)Show SMILES Cc1c(nn(-c2nc(cs2)C(O)=O)c1C(F)(F)F)-c1ccccc1 Show InChI InChI=1S/C15H10F3N3O2S/c1-8-11(9-5-3-2-4-6-9)20-21(12(8)15(16,17)18)14-19-10(7-24-14)13(22)23/h2-7H,1H3,(H,22,23) | KEGG
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| n/a | n/a | 84 | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description
Antagonist activity at human EP1 receptor by reporter gene assay |
Bioorg Med Chem Lett 23: 6064-7 (2013)
Article DOI: 10.1016/j.bmcl.2013.09.032
BindingDB Entry DOI: 10.7270/Q2959MJ5 |
More data for this
Ligand-Target Pair | |
Bromodomain-containing protein 4/Histone H4
(Homo sapiens (Human)) | BDBM179287
(US9125915, compound 12)Show SMILES Cc1nnc2C(CC(=O)Nc3cccnc3)N=C(c3c(C)c(C)sc3-n12)c1ccc(Cl)cc1 |c:17| Show InChI InChI=1S/C24H21ClN6OS/c1-13-14(2)33-24-21(13)22(16-6-8-17(25)9-7-16)28-19(23-30-29-15(3)31(23)24)11-20(32)27-18-5-4-10-26-12-18/h4-10,12,19H,11H2,1-3H3,(H,27,32) | PDB
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Mitsubishi Tanabe Pharma Corporation
US Patent
| Assay Description
An expression vector containing cDNA of BRD2, 3 and 4 added with Flag-tag was transfected to CHO cell, and a cell lysate was prepared 24 hr later. Bi... |
US Patent US9125915 (2015)
BindingDB Entry DOI: 10.7270/Q26972BJ |
More data for this
Ligand-Target Pair | |
Bromodomain-containing protein 4/Histone H4
(Homo sapiens (Human)) | BDBM179276
(US9125915, compound 7)Show SMILES COC(=O)C[C@@H]1N=C(c2c(C)c(CO)sc2-n2c(C)nnc12)c1ccc(cc1)-c1ccc(OC)cc1 |r,c:6| Show InChI InChI=1S/C27H26N4O4S/c1-15-22(14-32)36-27-24(15)25(28-21(13-23(33)35-4)26-30-29-16(2)31(26)27)19-7-5-17(6-8-19)18-9-11-20(34-3)12-10-18/h5-12,21,32H,13-14H2,1-4H3/t21-/m0/s1 | PDB
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| US Patent
| n/a | n/a | 113 | n/a | n/a | n/a | n/a | n/a | 25 |
Mitsubishi Tanabe Pharma Corporation
US Patent
| Assay Description
An expression vector containing cDNA of BRD2, 3 and 4 added with Flag-tag was transfected to CHO cell, and a cell lysate was prepared 24 hr later. Bi... |
US Patent US9125915 (2015)
BindingDB Entry DOI: 10.7270/Q26972BJ |
More data for this
Ligand-Target Pair | |
Bromodomain-containing protein 4/Histone H4
(Homo sapiens (Human)) | BDBM179291
(US9125915, compound 16)Show SMILES COc1ccc(NC(=O)C[C@@H]2N=C(c3c(C)c(C)sc3-n3c(C)nnc23)c2ccc(Cl)cc2)cn1 |r,c:11| Show InChI InChI=1S/C25H23ClN6O2S/c1-13-14(2)35-25-22(13)23(16-5-7-17(26)8-6-16)29-19(24-31-30-15(3)32(24)25)11-20(33)28-18-9-10-21(34-4)27-12-18/h5-10,12,19H,11H2,1-4H3,(H,28,33)/t19-/m0/s1 | PDB
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| n/a | n/a | 116 | n/a | n/a | n/a | n/a | n/a | 25 |
Mitsubishi Tanabe Pharma Corporation
US Patent
| Assay Description
An expression vector containing cDNA of BRD2, 3 and 4 added with Flag-tag was transfected to CHO cell, and a cell lysate was prepared 24 hr later. Bi... |
US Patent US9125915 (2015)
BindingDB Entry DOI: 10.7270/Q26972BJ |
More data for this
Ligand-Target Pair | |
Bromodomain-containing protein 4/Histone H4
(Homo sapiens (Human)) | BDBM179290
(US9125915, compound 15)Show SMILES Cc1sc-2c(c1C)C(=NC(CC(=O)Nc1ccc(N)cc1)c1nnc(C)n-21)c1ccc(Cl)cc1 |c:8| Show InChI InChI=1S/C25H23ClN6OS/c1-13-14(2)34-25-22(13)23(16-4-6-17(26)7-5-16)29-20(24-31-30-15(3)32(24)25)12-21(33)28-19-10-8-18(27)9-11-19/h4-11,20H,12,27H2,1-3H3,(H,28,33) | PDB
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| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | 25 |
Mitsubishi Tanabe Pharma Corporation
US Patent
| Assay Description
An expression vector containing cDNA of BRD2, 3 and 4 added with Flag-tag was transfected to CHO cell, and a cell lysate was prepared 24 hr later. Bi... |
US Patent US9125915 (2015)
BindingDB Entry DOI: 10.7270/Q26972BJ |
More data for this
Ligand-Target Pair | |
Bromodomain-containing protein 4/Histone H4
(Homo sapiens (Human)) | BDBM179275
(US9125915, compound 2)Show SMILES CCOC(=O)C[C@@H]1N=C(c2c(C)c(C)sc2-n2c(C)nnc12)c1ccc(Nc2cccc(c2)C#N)cc1 |r,c:7| Show InChI InChI=1S/C28H26N6O2S/c1-5-36-24(35)14-23-27-33-32-18(4)34(27)28-25(16(2)17(3)37-28)26(31-23)20-9-11-21(12-10-20)30-22-8-6-7-19(13-22)15-29/h6-13,23,30H,5,14H2,1-4H3/t23-/m0/s1 | PDB
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| n/a | n/a | 121 | n/a | n/a | n/a | n/a | n/a | 25 |
Mitsubishi Tanabe Pharma Corporation
US Patent
| Assay Description
An expression vector containing cDNA of BRD2, 3 and 4 added with Flag-tag was transfected to CHO cell, and a cell lysate was prepared 24 hr later. Bi... |
US Patent US9125915 (2015)
BindingDB Entry DOI: 10.7270/Q26972BJ |
More data for this
Ligand-Target Pair | |
Bromodomain-containing protein 4/Histone H4
(Homo sapiens (Human)) | BDBM179284
(US9125915, compound 8)Show SMILES COC(=O)C[C@@H]1N=C(c2c(C)c(C)sc2-n2c(C)nnc12)c1ccc(Nc2ccccc2)cc1 |r,c:6| Show InChI InChI=1S/C26H25N5O2S/c1-15-16(2)34-26-23(15)24(18-10-12-20(13-11-18)27-19-8-6-5-7-9-19)28-21(14-22(32)33-4)25-30-29-17(3)31(25)26/h5-13,21,27H,14H2,1-4H3/t21-/m0/s1 | PDB
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| n/a | n/a | 124 | n/a | n/a | n/a | n/a | n/a | 25 |
Mitsubishi Tanabe Pharma Corporation
US Patent
| Assay Description
An expression vector containing cDNA of BRD2, 3 and 4 added with Flag-tag was transfected to CHO cell, and a cell lysate was prepared 24 hr later. Bi... |
US Patent US9125915 (2015)
BindingDB Entry DOI: 10.7270/Q26972BJ |
More data for this
Ligand-Target Pair | |
Bromodomain-containing protein 4/Histone H4
(Homo sapiens (Human)) | BDBM179279
(US9125915, compound 18)Show SMILES COc1ncccc1NC(=O)C[C@@H]1N=C(c2c(C)c(C)sc2-n2c(C)nnc12)c1ccc(Cl)cc1 |r,c:14| Show InChI InChI=1S/C25H23ClN6O2S/c1-13-14(2)35-25-21(13)22(16-7-9-17(26)10-8-16)29-19(23-31-30-15(3)32(23)25)12-20(33)28-18-6-5-11-27-24(18)34-4/h5-11,19H,12H2,1-4H3,(H,28,33)/t19-/m0/s1 | PDB
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| n/a | n/a | 147 | n/a | n/a | n/a | n/a | n/a | 25 |
Mitsubishi Tanabe Pharma Corporation
US Patent
| Assay Description
An expression vector containing cDNA of BRD2, 3 and 4 added with Flag-tag was transfected to CHO cell, and a cell lysate was prepared 24 hr later. Bi... |
US Patent US9125915 (2015)
BindingDB Entry DOI: 10.7270/Q26972BJ |
More data for this
Ligand-Target Pair | |
A disintegrin and metalloproteinase with thrombospondin motifs 5
(Homo sapiens (Human)) | BDBM50445402
(CHEMBL3104658)Show InChI InChI=1S/C14H15N3OS/c1-2-5-11-14(18)17-13(19-11)8-12-15-9-6-3-4-7-10(9)16-12/h3-4,6-8,11H,2,5H2,1H3,(H,15,16)(H,17,18)/b13-8+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
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| CHEMBL
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UniChem
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| Article
PubMed
| n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant ADAMTS-5 using interglobular domain peptide of aggrecan after 60 mins by FRET assay |
Eur J Med Chem 71: 250-8 (2014)
Article DOI: 10.1016/j.ejmech.2013.10.075
BindingDB Entry DOI: 10.7270/Q2F76F15 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human)) | BDBM50493969
(CHEMBL2442490)Show SMILES OC(=O)c1csc(n1)-n1nc(cc1C(F)(F)F)-c1ccccc1O Show InChI InChI=1S/C14H8F3N3O3S/c15-14(16,17)11-5-8(7-3-1-2-4-10(7)21)19-20(11)13-18-9(6-24-13)12(22)23/h1-6,21H,(H,22,23) | KEGG
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PubMed
| n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description
Antagonist activity at human EP1 receptor by reporter gene assay |
Bioorg Med Chem Lett 23: 6064-7 (2013)
Article DOI: 10.1016/j.bmcl.2013.09.032
BindingDB Entry DOI: 10.7270/Q2959MJ5 |
More data for this
Ligand-Target Pair | |
Thromboxane A2 receptor
(Homo sapiens (Human)) | BDBM50444437
(CHEMBL3092130)Show SMILES Nc1c(nn(-c2nc(cs2)C(O)=O)c1-c1ccccc1)-c1ccccc1 Show InChI InChI=1S/C19H14N4O2S/c20-15-16(12-7-3-1-4-8-12)22-23(17(15)13-9-5-2-6-10-13)19-21-14(11-26-19)18(24)25/h1-11H,20H2,(H,24,25) | PDB
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| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description
Inhibition of TP receptor (unknown origin) |
Bioorg Med Chem Lett 23: 6569-76 (2013)
Article DOI: 10.1016/j.bmcl.2013.10.065
BindingDB Entry DOI: 10.7270/Q2BR8TMB |
More data for this
Ligand-Target Pair | |
Bromodomain-containing protein 4/Histone H4
(Homo sapiens (Human)) | BDBM179286
(US9125915, compound 11)Show SMILES CCOC(=O)C[C@@H]1N=C(c2c(C)c(C)sc2-n2c(C)nnc12)c1ccc(cc1)N(C)c1ccc(F)cc1 |r,c:7| Show InChI InChI=1S/C28H28FN5O2S/c1-6-36-24(35)15-23-27-32-31-18(4)34(27)28-25(16(2)17(3)37-28)26(30-23)19-7-11-21(12-8-19)33(5)22-13-9-20(29)10-14-22/h7-14,23H,6,15H2,1-5H3/t23-/m0/s1 | PDB
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| US Patent
| n/a | n/a | 225 | n/a | n/a | n/a | n/a | n/a | 25 |
Mitsubishi Tanabe Pharma Corporation
US Patent
| Assay Description
An expression vector containing cDNA of BRD2, 3 and 4 added with Flag-tag was transfected to CHO cell, and a cell lysate was prepared 24 hr later. Bi... |
US Patent US9125915 (2015)
BindingDB Entry DOI: 10.7270/Q26972BJ |
More data for this
Ligand-Target Pair | |
A disintegrin and metalloproteinase with thrombospondin motifs 5
(Homo sapiens (Human)) | BDBM50431947
(CHEMBL2348091)Show InChI InChI=1S/C15H13N3O3S2/c19-11-8-22-12(17-11)7-13-18-15(9-3-1-2-6-16-9)10(23-13)4-5-14(20)21/h1-3,6-7H,4-5,8H2,(H,17,19)(H,20,21)/b12-7+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 230 | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant ADAMTS-5 using interglobular domain peptide of aggrecan after 60 mins by FRET assay |
Eur J Med Chem 71: 250-8 (2014)
Article DOI: 10.1016/j.ejmech.2013.10.075
BindingDB Entry DOI: 10.7270/Q2F76F15 |
More data for this
Ligand-Target Pair | |
A disintegrin and metalloproteinase with thrombospondin motifs 5
(Homo sapiens (Human)) | BDBM50431947
(CHEMBL2348091)Show InChI InChI=1S/C15H13N3O3S2/c19-11-8-22-12(17-11)7-13-18-15(9-3-1-2-6-16-9)10(23-13)4-5-14(20)21/h1-3,6-7H,4-5,8H2,(H,17,19)(H,20,21)/b12-7+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 230 | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human His-tagged ADAMTS-5 using QF-peptide as substrate by FRET method |
Bioorg Med Chem Lett 23: 2106-10 (2013)
Article DOI: 10.1016/j.bmcl.2013.01.121
BindingDB Entry DOI: 10.7270/Q26974ZF |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human)) | BDBM50493970
(CHEMBL2442488)Show SMILES OC(=O)c1csc(n1)-n1nc(cc1C(F)(F)F)-c1ccc(O)cc1 Show InChI InChI=1S/C14H8F3N3O3S/c15-14(16,17)11-5-9(7-1-3-8(21)4-2-7)19-20(11)13-18-10(6-24-13)12(22)23/h1-6,21H,(H,22,23) | KEGG
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| Article
PubMed
| n/a | n/a | 320 | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description
Antagonist activity at human EP1 receptor by reporter gene assay |
Bioorg Med Chem Lett 23: 6064-7 (2013)
Article DOI: 10.1016/j.bmcl.2013.09.032
BindingDB Entry DOI: 10.7270/Q2959MJ5 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human)) | BDBM50250685
(CHEMBL1479261 | US10961200, Compound 62 | US112479...)Show InChI InChI=1S/C14H8F3N3O2S/c15-14(16,17)11-6-9(8-4-2-1-3-5-8)19-20(11)13-18-10(7-23-13)12(21)22/h1-7H,(H,21,22) | KEGG
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| n/a | n/a | 320 | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description
Antagonist activity at human EP1 receptor by reporter gene assay |
Bioorg Med Chem Lett 23: 6064-7 (2013)
Article DOI: 10.1016/j.bmcl.2013.09.032
BindingDB Entry DOI: 10.7270/Q2959MJ5 |
More data for this
Ligand-Target Pair | |
A disintegrin and metalloproteinase with thrombospondin motifs 5
(Homo sapiens (Human)) | BDBM50445403
(CHEMBL3104666)Show SMILES CCCC1SC(NC1=O)=Cc1nc2ccc(F)cc2[nH]1 |w:9.10| Show InChI InChI=1S/C14H14FN3OS/c1-2-3-11-14(19)18-13(20-11)7-12-16-9-5-4-8(15)6-10(9)17-12/h4-7,11H,2-3H2,1H3,(H,16,17)(H,18,19) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 380 | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant ADAMTS-5 using interglobular domain peptide of aggrecan after 60 mins by FRET assay |
Eur J Med Chem 71: 250-8 (2014)
Article DOI: 10.1016/j.ejmech.2013.10.075
BindingDB Entry DOI: 10.7270/Q2F76F15 |
More data for this
Ligand-Target Pair | |
A disintegrin and metalloproteinase with thrombospondin motifs 5
(Homo sapiens (Human)) | BDBM50431931
(CHEMBL2348077)Show InChI InChI=1S/C14H11N3O3S2/c18-10-7-21-11(16-10)6-12-17-14(8-3-1-2-4-15-8)9(22-12)5-13(19)20/h1-4,6H,5,7H2,(H,16,18)(H,19,20)/b11-6+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human His-tagged ADAMTS-5 using QF-peptide as substrate by FRET method |
Bioorg Med Chem Lett 23: 2106-10 (2013)
Article DOI: 10.1016/j.bmcl.2013.01.121
BindingDB Entry DOI: 10.7270/Q26974ZF |
More data for this
Ligand-Target Pair | |
A disintegrin and metalloproteinase with thrombospondin motifs 5
(Homo sapiens (Human)) | BDBM50445410
(CHEMBL3104659)Show InChI InChI=1S/C15H17N3OS/c1-2-3-8-12-15(19)18-14(20-12)9-13-16-10-6-4-5-7-11(10)17-13/h4-7,9,12H,2-3,8H2,1H3,(H,16,17)(H,18,19)/b14-9+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 410 | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant ADAMTS-5 using interglobular domain peptide of aggrecan after 60 mins by FRET assay |
Eur J Med Chem 71: 250-8 (2014)
Article DOI: 10.1016/j.ejmech.2013.10.075
BindingDB Entry DOI: 10.7270/Q2F76F15 |
More data for this
Ligand-Target Pair | |
A disintegrin and metalloproteinase with thrombospondin motifs 5
(Homo sapiens (Human)) | BDBM50128648
(1-Benzyl-4-[4-(4-chloro-phenoxy)-benzenesulfonyl]-...)Show SMILES ONC(=O)C1(CCN(Cc2ccccc2)CC1)S(=O)(=O)c1ccc(Oc2ccc(Cl)cc2)cc1 Show InChI InChI=1S/C25H25ClN2O5S/c26-20-6-8-21(9-7-20)33-22-10-12-23(13-11-22)34(31,32)25(24(29)27-30)14-16-28(17-15-25)18-19-4-2-1-3-5-19/h1-13,30H,14-18H2,(H,27,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 420 | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description
Inhibition of ADAMTS-5 (unknown origin) |
Bioorg Med Chem Lett 23: 2106-10 (2013)
Article DOI: 10.1016/j.bmcl.2013.01.121
BindingDB Entry DOI: 10.7270/Q26974ZF |
More data for this
Ligand-Target Pair | |
A disintegrin and metalloproteinase with thrombospondin motifs 5
(Homo sapiens (Human)) | BDBM50431949
(CHEMBL2348090)Show InChI InChI=1S/C14H11BrN2O3S3/c15-7-3-4-21-14(7)13-8(1-2-12(19)20)23-11(17-13)5-10-16-9(18)6-22-10/h3-5H,1-2,6H2,(H,16,18)(H,19,20)/b10-5+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 420 | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human His-tagged ADAMTS-5 using QF-peptide as substrate by FRET method |
Bioorg Med Chem Lett 23: 2106-10 (2013)
Article DOI: 10.1016/j.bmcl.2013.01.121
BindingDB Entry DOI: 10.7270/Q26974ZF |
More data for this
Ligand-Target Pair | |
A disintegrin and metalloproteinase with thrombospondin motifs 5
(Homo sapiens (Human)) | BDBM50445411
(CHEMBL3104657)Show InChI InChI=1S/C13H13N3OS/c1-2-10-13(17)16-12(18-10)7-11-14-8-5-3-4-6-9(8)15-11/h3-7,10H,2H2,1H3,(H,14,15)(H,16,17)/b12-7+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 420 | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant ADAMTS-5 using interglobular domain peptide of aggrecan after 60 mins by FRET assay |
Eur J Med Chem 71: 250-8 (2014)
Article DOI: 10.1016/j.ejmech.2013.10.075
BindingDB Entry DOI: 10.7270/Q2F76F15 |
More data for this
Ligand-Target Pair | |
A disintegrin and metalloproteinase with thrombospondin motifs 5
(Homo sapiens (Human)) | BDBM50431944
(CHEMBL2348087)Show InChI InChI=1S/C16H14N2O3S2/c19-12-9-22-13(17-12)8-14-18-16(10-4-2-1-3-5-10)11(23-14)6-7-15(20)21/h1-5,8H,6-7,9H2,(H,17,19)(H,20,21)/b13-8+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 420 | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human His-tagged ADAMTS-5 using QF-peptide as substrate by FRET method |
Bioorg Med Chem Lett 23: 2106-10 (2013)
Article DOI: 10.1016/j.bmcl.2013.01.121
BindingDB Entry DOI: 10.7270/Q26974ZF |
More data for this
Ligand-Target Pair | |
A disintegrin and metalloproteinase with thrombospondin motifs 5
(Homo sapiens (Human)) | BDBM50431950
(CHEMBL2348089)Show SMILES OC(=O)CCc1sc(\C=C2/NC(=O)CS2)nc1-c1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C22H18N2O3S2/c25-18-13-28-19(23-18)12-20-24-22(17(29-20)10-11-21(26)27)16-8-6-15(7-9-16)14-4-2-1-3-5-14/h1-9,12H,10-11,13H2,(H,23,25)(H,26,27)/b19-12+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 430 | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human His-tagged ADAMTS-5 using QF-peptide as substrate by FRET method |
Bioorg Med Chem Lett 23: 2106-10 (2013)
Article DOI: 10.1016/j.bmcl.2013.01.121
BindingDB Entry DOI: 10.7270/Q26974ZF |
More data for this
Ligand-Target Pair | |
A disintegrin and metalloproteinase with thrombospondin motifs 5
(Homo sapiens (Human)) | BDBM50445409
(CHEMBL3104660)Show InChI InChI=1S/C13H11N3O3S/c17-12(18)5-9-13(19)16-11(20-9)6-10-14-7-3-1-2-4-8(7)15-10/h1-4,6,9H,5H2,(H,14,15)(H,16,19)(H,17,18)/b11-6+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 430 | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant ADAMTS-5 using interglobular domain peptide of aggrecan after 60 mins by FRET assay |
Eur J Med Chem 71: 250-8 (2014)
Article DOI: 10.1016/j.ejmech.2013.10.075
BindingDB Entry DOI: 10.7270/Q2F76F15 |
More data for this
Ligand-Target Pair | |
A disintegrin and metalloproteinase with thrombospondin motifs 5
(Homo sapiens (Human)) | BDBM50431935
(CHEMBL2348073)Show SMILES OC(=O)Cc1sc(\C=C2/NC(=O)CS2)nc1-c1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C21H16N2O3S2/c24-17-12-27-18(22-17)11-19-23-21(16(28-19)10-20(25)26)15-8-6-14(7-9-15)13-4-2-1-3-5-13/h1-9,11H,10,12H2,(H,22,24)(H,25,26)/b18-11+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 430 | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human His-tagged ADAMTS-5 using QF-peptide as substrate by FRET method |
Bioorg Med Chem Lett 23: 2106-10 (2013)
Article DOI: 10.1016/j.bmcl.2013.01.121
BindingDB Entry DOI: 10.7270/Q26974ZF |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human)) | BDBM50493971
(CHEMBL2442486)Show SMILES COc1ccc(cc1)-c1cc(n(n1)-c1nc(cs1)C(O)=O)C(F)(F)F Show InChI InChI=1S/C15H10F3N3O3S/c1-24-9-4-2-8(3-5-9)10-6-12(15(16,17)18)21(20-10)14-19-11(7-25-14)13(22)23/h2-7H,1H3,(H,22,23) | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 430 | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description
Antagonist activity at human EP1 receptor by reporter gene assay |
Bioorg Med Chem Lett 23: 6064-7 (2013)
Article DOI: 10.1016/j.bmcl.2013.09.032
BindingDB Entry DOI: 10.7270/Q2959MJ5 |
More data for this
Ligand-Target Pair | |
A disintegrin and metalloproteinase with thrombospondin motifs 5
(Homo sapiens (Human)) | BDBM50445422
(CHEMBL3104673)Show InChI InChI=1S/C11H9N3OS/c15-10-6-16-11(14-10)5-9-12-7-3-1-2-4-8(7)13-9/h1-5H,6H2,(H,12,13)(H,14,15)/b11-5+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 470 | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant ADAMTS-5 using interglobular domain peptide of aggrecan after 60 mins by FRET assay |
Eur J Med Chem 71: 250-8 (2014)
Article DOI: 10.1016/j.ejmech.2013.10.075
BindingDB Entry DOI: 10.7270/Q2F76F15 |
More data for this
Ligand-Target Pair | |
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