| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Bifunctional dihydrofolate reductase-thymidylate synthase |
|---|
| Ligand | BDBM50041178 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_53475 (CHEMBL665600) |
|---|
| IC50 | 89300±n/a nM |
|---|
| Citation |  Gangjee, A; Devraj, R; McGuire, JJ; Kisliuk, RL; Queener, SF; Barrows, LR Classical and nonclassical furo[2,3-d]pyrimidines as novel antifolates: synthesis and biological activities. J Med Chem37:1169-76 (1994) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Bifunctional dihydrofolate reductase-thymidylate synthase |
|---|
| Name: | Bifunctional dihydrofolate reductase-thymidylate synthase |
|---|
| Synonyms: | DHFR-TS | DRTS_TOXGO | Dihydrofolate reductase | Dihydrofolate reductase (DHFR) | Dihydrofolate reductase; T. gondii vs rat |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 68757.49 |
|---|
| Organism: | Toxoplasma gondii |
|---|
| Description: | Q07422 |
|---|
| Residue: | 610 |
|---|
| Sequence: | MQKPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPEEASRLNGWLPRKFAKT
GDSGLPSPSVGKRFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEG
QQRVRVCASLPAALSLLEEEYKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVAREFPC
DVFFPAFPGDDILSNKSTAAQAAAPAESVFVPFCPELGREKDNEATYRPIFISKTFSDNG
VPYDFVVLEKRRKTDDAATAEPSNAMSSLTSTRETTPVHGLQAPSSAAAIAPVLAWMDEE
DRKKREQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYS
LDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHR
EVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAA
LDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKP
KEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVP
HGRIQMEMAV
|
|
|
|---|
| BDBM50041178 |
|---|
| n/a |
|---|
| Name | BDBM50041178 |
|---|
| Synonyms: | 5-((3,4-dichlorophenylamino)methyl)furo[2,3-d]pyrimidine-2,4-diamine | 5-[(3,4-Dichloro-phenylamino)-methyl]-furo[2,3-d]pyrimidine-2,4-diamine | CHEMBL274278 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C13H11Cl2N5O |
|---|
| Mol. Mass. | 324.165 |
|---|
| SMILES | Nc1nc(N)c2c(CNc3ccc(Cl)c(Cl)c3)coc2n1 |
|---|
| Structure | 
|
|---|
Search and Browse
