BindingDB PrimarySearch

Found 1089 hits with Last Name = 'devraj' and Initial = 'r'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50314073 (3-(3-bromo-4-(2,4-difluorobenzyloxy)-6-methyl-2-ox...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank MMDB PDB Article PubMed	2.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of p38alpha kinase				Bioorg Med Chem Lett 21: 3856-60 (2011) Article DOI: 10.1016/j.bmcl.2011.05.006 BindingDB Entry DOI: 10.7270/Q2G73F2S
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Mitogen-activated protein kinase 11 (Homo sapiens (Human))	BDBM50346920 (CHEMBL1795686) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of p38beta kinase				Bioorg Med Chem Lett 21: 3856-60 (2011) Article DOI: 10.1016/j.bmcl.2011.05.006 BindingDB Entry DOI: 10.7270/Q2G73F2S
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 11 (Homo sapiens (Human))	BDBM50346919 (CHEMBL1795685) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	17	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of p38beta kinase				Bioorg Med Chem Lett 21: 3856-60 (2011) Article DOI: 10.1016/j.bmcl.2011.05.006 BindingDB Entry DOI: 10.7270/Q2G73F2S
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 11 (Homo sapiens (Human))	BDBM50314073 (3-(3-bromo-4-(2,4-difluorobenzyloxy)-6-methyl-2-ox...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of p38beta kinase				Bioorg Med Chem Lett 21: 3856-60 (2011) Article DOI: 10.1016/j.bmcl.2011.05.006 BindingDB Entry DOI: 10.7270/Q2G73F2S
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50346918 (CHEMBL1738710) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	193	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of p38alpha kinase				Bioorg Med Chem Lett 21: 3856-60 (2011) Article DOI: 10.1016/j.bmcl.2011.05.006 BindingDB Entry DOI: 10.7270/Q2G73F2S
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Mitogen-activated protein kinase 9 (Homo sapiens (Human))	BDBM50314073 (3-(3-bromo-4-(2,4-difluorobenzyloxy)-6-methyl-2-ox...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	>4.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of JNK2				Bioorg Med Chem Lett 21: 3856-60 (2011) Article DOI: 10.1016/j.bmcl.2011.05.006 BindingDB Entry DOI: 10.7270/Q2G73F2S
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
C-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM50382932 (CHEMBL2029422) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of CCR2-mediated Erk phosphorylation				ACS Med Chem Lett 2: 913-918 (2011) Article DOI: 10.1021/ml200199c BindingDB Entry DOI: 10.7270/Q29024TK
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM18050 (2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank MMDB PDB PubMed	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibitory concentration of the compound against CCRF-CEM leukemic cell DHFR(Dihydro folate reductase).				J Med Chem 38: 3798-805 (1995) BindingDB Entry DOI: 10.7270/Q2FQ9VN5
Duquesne University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii)	BDBM50029766 (2,4-DIAMINO-5-METHYL-6-[(3,4,5-TRIMETHOXY-N-METHYL...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	0.850	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibitory concentration against Dihydrofolate reductase from Toxoplasma gondii (tg)				J Med Chem 40: 470-8 (1997) Article DOI: 10.1021/jm9606913 BindingDB Entry DOI: 10.7270/Q26W9968
Duquesne University Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50347099 (CHEMBL1797202) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assay				Bioorg Med Chem Lett 21: 4059-65 (2011) Article DOI: 10.1016/j.bmcl.2011.04.120 BindingDB Entry DOI: 10.7270/Q25Q4WFH
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Dihydrofolate reductase (Pneumocystis carinii)	BDBM18050 (2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibitory concentration of the compound for DHFR in Pneumocystis carinii				J Med Chem 37: 1169-76 (1994) BindingDB Entry DOI: 10.7270/Q2K64H4G
Duquesne University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50314073 (3-(3-bromo-4-(2,4-difluorobenzyloxy)-6-methyl-2-ox...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank MMDB PDB Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of p38alpha kinase-dependent HSP-27 phosphorylation in human U937 cells				Bioorg Med Chem Lett 21: 3856-60 (2011) Article DOI: 10.1016/j.bmcl.2011.05.006 BindingDB Entry DOI: 10.7270/Q2G73F2S
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM18224 (6-[(2,5-dimethoxyphenyl)methyl]-5-methylpyrido[2,3...) Show SMILES COc1ccc(OC)c(Cc2cnc3nc(N)nc(N)c3c2C)c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibitory concentration against Dihydrofolate reductase from Rat liver (rl)				J Med Chem 40: 470-8 (1997) Article DOI: 10.1021/jm9606913 BindingDB Entry DOI: 10.7270/Q26W9968
Duquesne University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
C-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM50382942 (CHEMBL2029423) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Antagonist activity at CCR2 receptor in human PBMC assessed as inhibition of MCP1-mediated leukocyte chemotaxis after 30 mins by microscopy				ACS Med Chem Lett 2: 913-918 (2011) Article DOI: 10.1021/ml200199c BindingDB Entry DOI: 10.7270/Q29024TK
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
C-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM50382939 (CHEMBL2029568) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Antagonist activity at CCR2 receptor in human PBMC assessed as inhibition of MCP1-mediated leukocyte chemotaxis after 30 mins by microscopy				ACS Med Chem Lett 2: 913-918 (2011) Article DOI: 10.1021/ml200199c BindingDB Entry DOI: 10.7270/Q29024TK
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50347100 (CHEMBL1797203) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assay				Bioorg Med Chem Lett 21: 4059-65 (2011) Article DOI: 10.1016/j.bmcl.2011.04.120 BindingDB Entry DOI: 10.7270/Q25Q4WFH
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50347929 (CHEMBL1802632) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of p38alpha assessed as phosphorylation FITC-labeled Hsp27 after 60 mins by fluorescence based cascade assay				Bioorg Med Chem Lett 21: 4066-71 (2011) Article DOI: 10.1016/j.bmcl.2011.04.121 BindingDB Entry DOI: 10.7270/Q2SB46R2
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50314073 (3-(3-bromo-4-(2,4-difluorobenzyloxy)-6-methyl-2-ox...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank MMDB PDB Article PubMed	n/a	n/a	2.30	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of p38alpha assessed as phosphorylation FITC-labeled Hsp27 after 60 mins by fluorescence based cascade assay				Bioorg Med Chem Lett 21: 4066-71 (2011) Article DOI: 10.1016/j.bmcl.2011.04.121 BindingDB Entry DOI: 10.7270/Q2SB46R2
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
C-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM50337608 (CHEMBL1683063 \| cis-((1S,3R)-3-(3-ethyl-tetrahydro...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.30	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation Curated by ChEMBL					Assay Description Antagonist activity at human CCR2 in human PBMC assessed as inhibition of MCP1-induced chemotaxis after 30 mins				Bioorg Med Chem Lett 21: 1442-6 (2011) Article DOI: 10.1016/j.bmcl.2011.01.015 BindingDB Entry DOI: 10.7270/Q22J6C4C
Incyte Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50314073 (3-(3-bromo-4-(2,4-difluorobenzyloxy)-6-methyl-2-ox...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank MMDB PDB Article PubMed	n/a	n/a	2.30	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of p38alpha assessed as phosphorylation FITC-labeled Hsp27 after 60 mins by fluorescence based cascade assay				Bioorg Med Chem Lett 21: 4066-71 (2011) Article DOI: 10.1016/j.bmcl.2011.04.121 BindingDB Entry DOI: 10.7270/Q2SB46R2
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
C-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM50337604 (CHEMBL1683059 \| Cis-((1S,3R)-1-isopropyl-3-(3-meth...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation Curated by ChEMBL					Assay Description Antagonist activity at human CCR2 in human PBMC assessed as inhibition of MCP1-induced chemotaxis after 30 mins				Bioorg Med Chem Lett 21: 1442-6 (2011) Article DOI: 10.1016/j.bmcl.2011.01.015 BindingDB Entry DOI: 10.7270/Q22J6C4C
Incyte Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50314073 (3-(3-bromo-4-(2,4-difluorobenzyloxy)-6-methyl-2-ox...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank MMDB PDB Article PubMed	n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of p38alpha assessed as phosphorylation FITC-labeled Hsp27 after 60 mins by fluorescence based cascade assay				Bioorg Med Chem Lett 21: 4066-71 (2011) Article DOI: 10.1016/j.bmcl.2011.04.121 BindingDB Entry DOI: 10.7270/Q2SB46R2
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
C-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM50382933 (CHEMBL2029419) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Antagonist activity at CCR2 receptor in human PBMC assessed as inhibition of MCP1-mediated leukocyte chemotaxis after 30 mins by microscopy				ACS Med Chem Lett 2: 913-918 (2011) Article DOI: 10.1021/ml200199c BindingDB Entry DOI: 10.7270/Q29024TK
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
C-C chemokine receptor type 2 (Rattus norvegicus)	BDBM50382932 (CHEMBL2029422) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Antagonist activity at rat CCR2				ACS Med Chem Lett 2: 913-918 (2011) Article DOI: 10.1021/ml200199c BindingDB Entry DOI: 10.7270/Q29024TK
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
C-C chemokine receptor type 2 (Mus musculus)	BDBM50337619 (((1S,3R)-1-isopropyl-3-((3S,4S)-3-methoxytetrahydr...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation Curated by ChEMBL					Assay Description Binding affinity to mouse CCR2				Bioorg Med Chem Lett 21: 1442-6 (2011) Article DOI: 10.1016/j.bmcl.2011.01.015 BindingDB Entry DOI: 10.7270/Q22J6C4C
Incyte Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
C-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM50338145 ((1S,4S)-tert-butyl 5-((1S,3R)-1-isopropyl-3-((3S,4...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.90	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Displacement of [125I]MCP1 from human CCR2 preincubated 1 hrs by human whole cell binding assay				Bioorg Med Chem Lett 21: 1827-31 (2011) Article DOI: 10.1016/j.bmcl.2011.01.052 BindingDB Entry DOI: 10.7270/Q2GM87M5
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
C-C chemokine receptor type 2 (Rattus norvegicus)	BDBM50337619 (((1S,3R)-1-isopropyl-3-((3S,4S)-3-methoxytetrahydr...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.90	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation Curated by ChEMBL					Assay Description Binding affinity to rat CCR2				Bioorg Med Chem Lett 21: 1442-6 (2011) Article DOI: 10.1016/j.bmcl.2011.01.015 BindingDB Entry DOI: 10.7270/Q22J6C4C
Incyte Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM18268 (5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibitory concentration against Dihydrofolate reductase from Rat liver (rl)				J Med Chem 40: 470-8 (1997) Article DOI: 10.1021/jm9606913 BindingDB Entry DOI: 10.7270/Q26W9968
Duquesne University Curated by ChEMBL					More data for this Ligand-Target Pair
C-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM50337619 (((1S,3R)-1-isopropyl-3-((3S,4S)-3-methoxytetrahydr...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation Curated by ChEMBL					Assay Description Displacement of [125I]MCP1 from human CCR2 after 30 mins by gamma counting				Bioorg Med Chem Lett 21: 1442-6 (2011) Article DOI: 10.1016/j.bmcl.2011.01.015 BindingDB Entry DOI: 10.7270/Q22J6C4C
Incyte Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50347938 (CHEMBL1802637) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of p38alpha assessed as phosphorylation FITC-labeled Hsp27 after 60 mins by fluorescence based cascade assay				Bioorg Med Chem Lett 21: 4066-71 (2011) Article DOI: 10.1016/j.bmcl.2011.04.121 BindingDB Entry DOI: 10.7270/Q2SB46R2
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
C-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM50337619 (((1S,3R)-1-isopropyl-3-((3S,4S)-3-methoxytetrahydr...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Displacement of [125I]MCP1 from human CCR2 preincubated for 30 mins by human whole cell binding assay				Bioorg Med Chem Lett 21: 2626-30 (2011) Article DOI: 10.1016/j.bmcl.2011.01.034 BindingDB Entry DOI: 10.7270/Q2CJ8DT9
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50347106 (CHEMBL1797209) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assay				Bioorg Med Chem Lett 21: 4059-65 (2011) Article DOI: 10.1016/j.bmcl.2011.04.120 BindingDB Entry DOI: 10.7270/Q25Q4WFH
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50347096 (CHEMBL1797123) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assay				Bioorg Med Chem Lett 21: 4059-65 (2011) Article DOI: 10.1016/j.bmcl.2011.04.120 BindingDB Entry DOI: 10.7270/Q25Q4WFH
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
C-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM50337619 (((1S,3R)-1-isopropyl-3-((3S,4S)-3-methoxytetrahydr...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Displacement of [125I]MCP1 from human CCR2 by human whole cell binding assay				Bioorg Med Chem Lett 21: 1827-31 (2011) Article DOI: 10.1016/j.bmcl.2011.01.052 BindingDB Entry DOI: 10.7270/Q2GM87M5
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM18050 (2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibitory concentration of the compound for DHFR in rat liver				J Med Chem 37: 1169-76 (1994) BindingDB Entry DOI: 10.7270/Q2K64H4G
Duquesne University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
C-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM50338141 ((1S,4S)-cyclopentyl 5-((1S,3R)-3-(3-fluorotetrahyd...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.10	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Displacement of [125I]MCP1 from human CCR2 preincubated 30 mins by human whole cell binding assay				Bioorg Med Chem Lett 21: 1827-31 (2011) Article DOI: 10.1016/j.bmcl.2011.01.052 BindingDB Entry DOI: 10.7270/Q2GM87M5
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
C-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM50337604 (CHEMBL1683059 \| Cis-((1S,3R)-1-isopropyl-3-(3-meth...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.10	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation Curated by ChEMBL					Assay Description Displacement of [125I]MCP1 from human CCR2 after 30 mins by gamma counting				Bioorg Med Chem Lett 21: 1442-6 (2011) Article DOI: 10.1016/j.bmcl.2011.01.015 BindingDB Entry DOI: 10.7270/Q22J6C4C
Incyte Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
C-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM50337619 (((1S,3R)-1-isopropyl-3-((3S,4S)-3-methoxytetrahydr...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at human CCR2 assessed as inhibition of MCP1-induced chemotaxis by cell based assay				Bioorg Med Chem Lett 21: 2626-30 (2011) Article DOI: 10.1016/j.bmcl.2011.01.034 BindingDB Entry DOI: 10.7270/Q2CJ8DT9
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
C-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM50337634 (((1S,3R)-3-((3S,4S)-3-methoxy-tetrahydro-2H-pyran-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation Curated by ChEMBL					Assay Description Displacement of MCP-Alexa 488 from CCR2 in human whole blood after 5 mins by flow cytometry				Bioorg Med Chem Lett 21: 1442-6 (2011) Article DOI: 10.1016/j.bmcl.2011.01.015 BindingDB Entry DOI: 10.7270/Q22J6C4C
Incyte Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
C-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM50338135 ((1S,4S)-1,1,1-trifluoropropan-2-yl 5-((1S,3R)-3-(3...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Displacement of [125I]MCP1 from human CCR2 preincubated 30 mins by human whole cell binding assay				Bioorg Med Chem Lett 21: 1827-31 (2011) Article DOI: 10.1016/j.bmcl.2011.01.052 BindingDB Entry DOI: 10.7270/Q2GM87M5
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
C-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM50337619 (((1S,3R)-1-isopropyl-3-((3S,4S)-3-methoxytetrahydr...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation Curated by ChEMBL					Assay Description Antagonist activity at human CCR2 in human PBMC assessed as inhibition of MCP1-induced chemotaxis after 30 mins				Bioorg Med Chem Lett 21: 1442-6 (2011) Article DOI: 10.1016/j.bmcl.2011.01.015 BindingDB Entry DOI: 10.7270/Q22J6C4C
Incyte Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
C-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM50382935 (CHEMBL2029572) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Displacement of [125I]MCP1 from human CCR2 in PBMC after 30 mins by gamma counting				ACS Med Chem Lett 2: 913-918 (2011) Article DOI: 10.1021/ml200199c BindingDB Entry DOI: 10.7270/Q29024TK
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
C-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM50382939 (CHEMBL2029568) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Displacement of [125I]MCP1 from human CCR2 in PBMC after 30 mins by gamma counting				ACS Med Chem Lett 2: 913-918 (2011) Article DOI: 10.1021/ml200199c BindingDB Entry DOI: 10.7270/Q29024TK
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
C-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM50382932 (CHEMBL2029422) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of CCR2-mediated calcium mobilization				ACS Med Chem Lett 2: 913-918 (2011) Article DOI: 10.1021/ml200199c BindingDB Entry DOI: 10.7270/Q29024TK
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
C-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM50337634 (((1S,3R)-3-((3S,4S)-3-methoxy-tetrahydro-2H-pyran-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.40	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation Curated by ChEMBL					Assay Description Displacement of [125I]MCP1 from human CCR2 after 30 mins by gamma counting				Bioorg Med Chem Lett 21: 1442-6 (2011) Article DOI: 10.1016/j.bmcl.2011.01.015 BindingDB Entry DOI: 10.7270/Q22J6C4C
Incyte Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
C-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM50382941 (CHEMBL2029424) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Antagonist activity at CCR2 receptor in human PBMC assessed as inhibition of MCP1-mediated leukocyte chemotaxis after 30 mins by microscopy				ACS Med Chem Lett 2: 913-918 (2011) Article DOI: 10.1021/ml200199c BindingDB Entry DOI: 10.7270/Q29024TK
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
C-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM50338129 ((1S,4S)-1,1,1-trifluoropropan-2-yl 5-((1S,3R)-1-is...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Displacement of [125I]MCP1 from human CCR2 preincubated 30 mins by human whole cell binding assay				Bioorg Med Chem Lett 21: 1827-31 (2011) Article DOI: 10.1016/j.bmcl.2011.01.052 BindingDB Entry DOI: 10.7270/Q2GM87M5
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
C-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM50382940 (CHEMBL2029566) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Displacement of [125I]MCP1 from human CCR2 in PBMC after 30 mins by gamma counting				ACS Med Chem Lett 2: 913-918 (2011) Article DOI: 10.1021/ml200199c BindingDB Entry DOI: 10.7270/Q29024TK
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
C-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM50363953 (CHEMBL1951778 \| CHEMBL1963131) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Displacement of [125I]MCP1 from human CCR2 in PBMC after 30 mins by gamma counting				ACS Med Chem Lett 2: 913-918 (2011) Article DOI: 10.1021/ml200199c BindingDB Entry DOI: 10.7270/Q29024TK
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
C-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM50382943 (CHEMBL2029421) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.80	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Antagonist activity at CCR2 receptor in human PBMC assessed as inhibition of MCP1-mediated leukocyte chemotaxis after 30 mins by microscopy				ACS Med Chem Lett 2: 913-918 (2011) Article DOI: 10.1021/ml200199c BindingDB Entry DOI: 10.7270/Q29024TK
TBA Curated by ChEMBL					More data for this Ligand-Target Pair

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