| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dihydrofolate reductase |
|---|
| Ligand | BDBM50041932 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_55135 |
|---|
| IC50 | 3900±n/a nM |
|---|
| Citation |  Rosowsky, A; Mota, CE; Wright, JE; Freisheim, JH; Heusner, JJ; McCormack, JJ; Queener, SF 2,4-Diaminothieno[2,3-d]pyrimidine analogues of trimetrexate and piritrexim as potential inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase. J Med Chem36:3103-12 (1993) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Dihydrofolate reductase |
|---|
| Name: | Dihydrofolate reductase |
|---|
| Synonyms: | DYR_RAT | Dhfr | Dihydrofolate reductase (DHFR) | Dihydrofolate reductase; P. carinii vs rat | Tetrahydrofolate dehydrogenase |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 21638.84 |
|---|
| Organism: | Rattus norvegicus (rat) |
|---|
| Description: | n/a |
|---|
| Residue: | 187 |
|---|
| Sequence: | MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFS
IPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSS
VYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKF
EVYEKKD
|
|
|
|---|
| BDBM50041932 |
|---|
| n/a |
|---|
| Name | BDBM50041932 |
|---|
| Synonyms: | 5,6,7,8-Tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidine-2,4-diamine | CHEMBL323155 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C10H12N4S |
|---|
| Mol. Mass. | 220.294 |
|---|
| SMILES | Nc1nc(N)c2c3CCCCc3sc2n1 |
|---|
| Structure | 
|
|---|
Search and Browse
