Reaction Details |
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Target | Dihydrofolate reductase |
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Ligand | BDBM50041939 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_54130 |
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IC50 | >10000±n/a nM |
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Citation | Rosowsky, A; Mota, CE; Wright, JE; Freisheim, JH; Heusner, JJ; McCormack, JJ; Queener, SF 2,4-Diaminothieno[2,3-d]pyrimidine analogues of trimetrexate and piritrexim as potential inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase. J Med Chem36:3103-12 (1993) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Dihydrofolate reductase |
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Name: | Dihydrofolate reductase |
Synonyms: | DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
Type: | Enzyme |
Mol. Mass.: | 21453.99 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant human DHFR. |
Residue: | 187 |
Sequence: | MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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BDBM50041939 |
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n/a |
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Name | BDBM50041939 |
Synonyms: | 5-Methyl-6-(3,4,5-trimethoxy-phenyl)-thieno[2,3-d]pyrimidine-2,4-diamine | CHEMBL326200 |
Type | Small organic molecule |
Emp. Form. | C16H18N4O3S |
Mol. Mass. | 346.404 |
SMILES | COc1cc(cc(OC)c1OC)-c1sc2nc(N)nc(N)c2c1C |
Structure |
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