| Reaction Details |
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 | Report a problem with these data |
| Target | Prostaglandin G/H synthase 1 |
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| Ligand | BDBM185731 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1284733 (CHEMBL3107542) |
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| IC50 | >10000±n/a nM |
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| Citation |  Biava, M; Battilocchio, C; Poce, G; Alfonso, S; Consalvi, S; Di Capua, A; Calderone, V; Martelli, A; Testai, L; Sautebin, L; Rossi, A; Ghelardini, C; Di Cesare Mannelli, L; Giordani, A; Persiani, S; Colovic, M; Dovizio, M; Patrignani, P; Anzini, M Enhancing the pharmacodynamic profile of a class of selective COX-2 inhibiting nitric oxide donors. Bioorg Med Chem22:772-86 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prostaglandin G/H synthase 1 |
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| Name: | Prostaglandin G/H synthase 1 |
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| Synonyms: | Cox-1 | Cox1 | Cyclooxygenase-1 | PGH synthase 1 | PGH1_MOUSE | PGHS-1 | PHS 1 | Prostaglandin G/H synthase (cyclooxygenase) | Prostaglandin H2 synthase 1 | Prostaglandin-endoperoxide synthase 1 | Ptgs1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 69044.61 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_10575 |
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| Residue: | 602 |
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| Sequence: | MSRRSLSLWFPLLLLLLLPPTPSVLLADPGVPSPVNPCCYYPCQNQGVCVRFGLDNYQCD
CTRTGYSGPNCTIPEIWTWLRNSLRPSPSFTHFLLTHGYWLWEFVNATFIREVLMRLVLT
VRSNLIPSPPTYNSAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDVQLLA
QQLLLRREFIPAPQGTNILFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNL
ERQYHLRLFKDGKLKYQVLDGEVYPPSVEQASVLMRYPPGVPPERQMAVGQEVFGLLPGL
MLFSTIWLREHNRVCDLLKEEHPTWDDEQLFQTTRLILIGETIKIVIEEYVQHLSGYFLQ
LKFDPELLFRAQFQYRNRIAMEFNHLYHWHPLMPNSFQVGSQEYSYEQFLFNTSMLVDYG
VEALVDAFSRQRAGRIGGGRNFDYHVLHVAVDVIKESREMRLQPFNEYRKRFGLKPYTSF
QELTGEKEMAAELEELYGDIDALEFYPGLLLEKCQPNSIFGESMIEMGAPFSLKGLLGNP
ICSPEYWKPSTFGGDVGFNLVNTASLKKLVCLNTKTCPYVSFRVPDYPGDDGSVLVRRST
EL
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| BDBM185731 |
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| n/a |
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| Name | BDBM185731 |
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| Synonyms: | US9162979, 26-II |
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| Type | Small organic molecule |
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| Emp. Form. | C23H25FN2O4S |
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| Mol. Mass. | 444.519 |
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| SMILES | Cc1c(CC(=O)NCCCO)cc(-c2ccc(cc2)S(C)(=O)=O)n1-c1ccc(F)cc1 |
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| Structure | 
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