| Reaction Details |
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 | Report a problem with these data |
| Target | Thromboxane-A synthase |
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| Ligand | BDBM50043282 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_207794 (CHEMBL880941) |
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| IC50 | 3300±n/a nM |
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| Citation |  Yamaguchi, M; Kamei, K; Koga, T; Akima, M; Maruyama, A; Kuroki, T; Ohi, N Novel antiasthmatic agents with dual activities of thromboxane A2 synthetase inhibition and bronchodilation. 2. 4-(3-Pyridyl)-1(2H)-phthalazinones. J Med Chem36:4061-8 (1994) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Thromboxane-A synthase |
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| Name: | Thromboxane-A synthase |
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| Synonyms: | Cyp5 | Cyp5a1 | Cytochrome P450 5A1 | THAS_RAT | TXA synthase | TXS | Tbxas1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 59971.80 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_209768 |
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| Residue: | 533 |
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| Sequence: | MEVLGLLKFEVSGTVVTVTLSVVLLALLKWYSTSAFSRLRKLGIRHPEPSPFVGNLMFFR
QGFWESHLELRERYGPLCGYYLGRRMYIVISDPDMIKEVLVENFSNFSNRMASGLEPKLI
ADSVLMLRDRRWEEVRGALMSAFSPEKLNEMTPLISQACELLLSHLKHSAASGDAFDIQR
CYCCFTTNVVASVAFGIEVNSQDAPEDPFVQHCQRVFAFSTPRPLLALILSFPSIMVPLA
RILPNKNRDELNGFFNTLIRNVIALRDKQTAEERRGDFLQMVLDAQRSMSSVGVEAFDMV
TEALSSAECMGDPPQRCHPTSTAKPLTVDEIAGQAFLFLIAGHEITTNTLSFITYLLATH
PECQERLLKEVDLFMEKHPAPEYCNLQEGLPYLDMVVAETLRMYPPAFRFTREAAQDCEV
LGQHIPAGSVLEIAVGALHHDPEHWPNPETFDPERFTAEARLQQKPFTYLPFGAGPRSCL
GVRLGLLVVKLTLLQVLHKFRFEACPETQVPLQLESKSALCPKNGVYVKIVSR
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| BDBM50043282 |
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| n/a |
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| Name | BDBM50043282 |
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| Synonyms: | 2-Methyl-4-thiazol-5-yl-2H-phthalazin-1-one | CHEMBL130453 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H9N3OS |
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| Mol. Mass. | 243.284 |
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| SMILES | Cn1nc(-c2cncs2)c2ccccc2c1=O |
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| Structure | 
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