| Reaction Details |
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 | Report a problem with these data |
| Target | RNA-directed RNA polymerase |
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| Ligand | BDBM50497155 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1362875 (CHEMBL3291649) |
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| IC50 | 380±n/a nM |
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| Citation |  Chapron, C; Glen, R; La Colla, M; Mayes, BA; McCarville, JF; Moore, S; Moussa, A; Sarkar, R; Seifer, M; Serra, I; Stewart, A Synthesis of 2'-O,4'-C-alkylene-bridged ribonucleosides and their evaluation as inhibitors of HCV NS5B polymerase. Bioorg Med Chem Lett24:2699-702 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| RNA-directed RNA polymerase |
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| Name: | RNA-directed RNA polymerase |
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| Synonyms: | 2.7.7.48 | NS5b | RNA-directed RNA polymerase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 65779.30 |
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| Organism: | Hepacivirus C |
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| Description: | ChEMBL_118447 |
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| Residue: | 591 |
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| Sequence: | SMSYTWTGALITPCAAEESKLPINALSNSLLRHHNMVYATTSRSASLRQKKVTFDRLQVL
DDHYRDVLKEMKAKASTVKAKLLSVEEACKLTPPHSAKSKFGYGAKDVRNLSSKAVNHIR
SVWKDLLEDTETPIDTTIMAKNEVFCVQPEKGGRKPARLIVFPDLGVRVCEKMALYDVVS
TLPQAVMGSSYGFQYSPGQRVEFLVNTWKSKKCPMGFSYDTRCFDSTVTENDIRVEESIY
QCCDLAPEARQAIRSLTERLYIGGPLTNSKGQNCGYRRCRASGVLTTSCGNTLTCYLKAS
AACRAAKLQDCTMLVCGDDLVVICESAGTQEDAASLRAFTEAMTRYSAPPGDPPQPEYDL
ELITSCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMYAPTLW
ARMILMTHFFSILLAQEQLEKALDCQIYGACYSIEPLDLPQIIQRLHGLSAFSLHSYSPG
EINRVASCLRKLGVPPLRVWRHRARSVRARLLSQGGRAATCGKYLFNWAVRTKLKLTPIP
AASQLDLSSWFVAGYSGGDIYHSLSRARPRWFMWCLLLLSVGVGIYLLPNR
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| BDBM50497155 |
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| n/a |
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| Name | BDBM50497155 |
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| Synonyms: | CHEMBL3291362 |
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| Type | Small organic molecule |
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| Emp. Form. | C11H16N5O14P3 |
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| Mol. Mass. | 535.1911 |
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| SMILES | [H][C@]12OC[C@](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)(O[C@H]1n1cnc3c1nc(N)[nH]c3=O)[C@H]2O |r,THB:33:32:3.2:19.20| |
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| Structure | 
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