| Reaction Details |
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 | Report a problem with these data |
| Target | Pepsin A-5 |
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| Ligand | BDBM50008139 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_153845 |
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| Ki | 11±n/a nM |
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| Citation |  Rao, CM; Scarborough, PE; Kay, J; Batley, B; Rapundalo, S; Klutchko, S; Taylor, MD; Lunney, EA; Humblet, CC; Dunn, BM Specificity in the binding of inhibitors to the active site of human/primate aspartic proteinases: analysis of P2-P1-P1'-P2' variation. J Med Chem36:2614-20 (1993) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Pepsin A-5 |
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| Name: | Pepsin A-5 |
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| Synonyms: | PEPA5_HUMAN | PGA5 | Pepsin A | Pepsinogen A5 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 41971.56 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1452206 |
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| Residue: | 388 |
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| Sequence: | MKWLLLLGLVALSECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWEAP
TLVDEQPLENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFNP
EDSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFD
GILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSADDKSGSVVIFGGIDSSYYTGS
LNWVPVTVEGYWQITVDSITMNGETIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGAS
ENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQSEGSCISGFQGMNVPTESGEL
WILGDVFIRQYFTVFDRANNQVGLAPVA
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| BDBM50008139 |
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| n/a |
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| Name | BDBM50008139 |
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| Synonyms: | 2-[2-(Morpholine-4-sulfonylamino)-3-phenyl-propionylamino]-pent-4-enoic acid [1-cyclohexylmethyl-3,3-difluoro-3-(2-morpholin-4-yl-ethylcarbamoyl)-2-oxo-propyl]-amide | 2-[2-(Morpholine-4-sulfonylamino)-3-phenyl-propionylamino]-pent-4-enoic acid [1-cyclohexylmethyl-3,3-difluoro-3-(2-morpholin-4-yl-ethylcarbamoyl)-2-oxo-propyl]-amide; Hydrate; CH3SO3H | CHEMBL287423 |
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| Type | Small organic molecule |
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| Emp. Form. | C35H52F2N6O8S |
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| Mol. Mass. | 754.885 |
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| SMILES | FC(F)(C(=O)NCCN1CCOCC1)C(=O)[C@H](CC1CCCCC1)NC(=O)[C@H](CC=C)NC(=O)[C@H](Cc1ccccc1)NS(=O)(=O)N1CCOCC1 |
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| Structure | 
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