| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cathepsin D |
|---|
| Ligand | BDBM50045289 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_45168 |
|---|
| Ki | 45±n/a nM |
|---|
| Citation |  Rao, CM; Scarborough, PE; Kay, J; Batley, B; Rapundalo, S; Klutchko, S; Taylor, MD; Lunney, EA; Humblet, CC; Dunn, BM Specificity in the binding of inhibitors to the active site of human/primate aspartic proteinases: analysis of P2-P1-P1'-P2' variation. J Med Chem36:2614-20 (1993) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cathepsin D |
|---|
| Name: | Cathepsin D |
|---|
| Synonyms: | CATD_HUMAN | CPSD | CTSD | Cathepsin D [Precursor] | Cathepsin D heavy chain | Cathepsin D light chain | Cathepsin D precursor |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 44551.72 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Human proCathepsin D (SwissProt accession number P07339) was expressed in Sf9 cells, purified, and autoactivated. |
|---|
| Residue: | 412 |
|---|
| Sequence: | MQPSSLLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVP
AVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIH
HKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFG
EATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQ
PGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSL
MVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQ
AGKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAARL
|
|
|
|---|
| BDBM50045289 |
|---|
| n/a |
|---|
| Name | BDBM50045289 |
|---|
| Synonyms: | 6-(3-Methyl-thioureido)-2-[2-(morpholine-4-sulfonylamino)-3-phenyl-propionylamino]-hexanoic acid (1-cyclohexylmethyl-2,4-dihydroxy-hexyl)-amide | CHEMBL418948 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C34H58N6O7S2 |
|---|
| Mol. Mass. | 726.99 |
|---|
| SMILES | CC[C@H](O)C[C@H](O)[C@H](CC1CCCCC1)NC(=O)[C@H](CCCCNC(=S)NC)NC(=O)[C@H](Cc1ccccc1)NS(=O)(=O)N1CCOCC1 |
|---|
| Structure | 
|
|---|
Search and Browse
