| Reaction Details |
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 | Report a problem with these data |
| Target | G protein-activated inward rectifier potassium channel 1 |
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| Ligand | BDBM50497415 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1443118 (CHEMBL3371678) |
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| IC50 | 2000±n/a nM |
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| Citation |  Wen, W; Wu, W; Weaver, CD; Lindsley, CW Discovery of potent and selective GIRK1/2 modulators via 'molecular switches' within a series of 1-(3-cyclopropyl-1-phenyl-1H-pyrazol-5-yl)ureas. Bioorg Med Chem Lett24:5102-6 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| G protein-activated inward rectifier potassium channel 1 |
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| Name: | G protein-activated inward rectifier potassium channel 1 |
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| Synonyms: | GIRK-1 | GIRK1 | Inward rectifier K(+) channel Kir3.1 | KCNJ3 | KCNJ3_HUMAN | Potassium channel, inwardly rectifying subfamily J member 3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 56610.74 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_107915 |
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| Residue: | 501 |
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| Sequence: | MSALRRKFGDDYQVVTTSSSGSGLQPQGPGQDPQQQLVPKKKRQRFVDKNGRCNVQHGNL
GSETSRYLSDLFTTLVDLKWRWNLFIFILTYTVAWLFMASMWWVIAYTRGDLNKAHVGNY
TPCVANVYNFPSAFLFFIETEATIGYGYRYITDKCPEGIILFLFQSILGSIVDAFLIGCM
FIKMSQPKKRAETLMFSEHAVISMRDGKLTLMFRVGNLRNSHMVSAQIRCKLLKSRQTPE
GEFLPLDQLELDVGFSTGADQLFLVSPLTICHVIDAKSPFYDLSQRSMQTEQFEIVVILE
GIVETTGMTCQARTSYTEDEVLWGHRFFPVISLEEGFFKVDYSQFHATFEVPTPPYSVKE
QEEMLLMSSPLIAPAITNSKERHNSVECLDGLDDITTKLPSKLQKITGREDFPKKLLRMS
STTSEKAYSLGDLPMKLQRISSVPGNSEEKLVSKTTKMLSDPMSQSVADLPPKLQKMAGG
AARMEGNLPAKLRKMNSDRFT
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| BDBM50497415 |
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| n/a |
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| Name | BDBM50497415 |
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| Synonyms: | CHEMBL3339104 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H20N4O2 |
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| Mol. Mass. | 348.3984 |
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| SMILES | COc1ccc(NC(=O)Nc2cc(nn2-c2ccccc2)C2CC2)cc1 |
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| Structure | 
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