| Reaction Details |
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 | Report a problem with these data |
| Target | Gag-Pol polyprotein [489-587] |
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| Ligand | BDBM50046443 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_159311 (CHEMBL769364) |
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| IC50 | 13±n/a nM |
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| Citation |  Kempf, DJ; Codacovi, L; Wang, XC; Kohlbrenner, WE; Wideburg, NE; Saldivar, A; Vasavanonda, S; Marsh, KC; Bryant, P; Sham, HL Symmetry-based inhibitors of HIV protease. Structure-activity studies of acylated 2,4-diamino-1,5-diphenyl-3-hydroxypentane and 2,5-diamino-1,6-diphenylhexane-3,4-diol. J Med Chem36:320-30 (1993) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Gag-Pol polyprotein [489-587] |
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| Name: | Gag-Pol polyprotein [489-587] |
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| Synonyms: | Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 10781.16 |
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| Organism: | Human immunodeficiency virus type 1 |
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| Description: | P04585[489-587] |
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| Residue: | 99 |
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| Sequence: | PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
|
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| BDBM50046443 |
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| n/a |
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| Name | BDBM50046443 |
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| Synonyms: | CHEMBL113264 | {1-[1-Benzyl-3-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)-2-hydroxy-4-phenyl-butylcarbamoyl]-2-methyl-propyl}-carbamic acid 1-methyl-piperidin-3-ylmethyl ester |
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| Type | Small organic molecule |
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| Emp. Form. | C43H59N5O7 |
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| Mol. Mass. | 757.9579 |
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| SMILES | CC(C)[C@H](NC(=O)OCC1CCCN(C)C1)C(=O)N[C@@H](Cc1ccccc1)[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](NC(=O)OCc1ccccc1)C(C)C |
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| Structure | 
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