Reaction Details |
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Target | 5-hydroxytryptamine receptor 4 |
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Ligand | BDBM50436989 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1541145 (CHEMBL3744754) |
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EC50 | 8.6±n/a nM |
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Citation | Nirogi, R; Mohammed, AR; Shinde, AK; Bogaraju, N; Gagginapalli, SR; Ravella, SR; Kota, L; Bhyrapuneni, G; Muddana, NR; Benade, V; Palacharla, RC; Jayarajan, P; Subramanian, R; Goyal, VK Synthesis and SAR of Imidazo[1,5-a]pyridine derivatives as 5-HT4 receptor partial agonists for the treatment of cognitive disorders associated with Alzheimer's disease. Eur J Med Chem103:289-301 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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5-hydroxytryptamine receptor 4 |
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Name: | 5-hydroxytryptamine receptor 4 |
Synonyms: | 5-HT4 | 5-hydroxytryptamine receptor 4 | 5HT4R_CAVPO | HTR4 | Serotonin 4 (5-HT4) receptor |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 43735.29 |
Organism: | GUINEA PIG |
Description: | 5-HT4 HTR4 GUINEA PIG::O70528 |
Residue: | 388 |
Sequence: | MDKLDANVSSKEGFGSVEKVVLLTFLSAVILMAILGNLLVMVAVCRDRQLRKIKTNYFIV
SLAFADLLVSVLVMPFGAIELVQDIWVYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYY
AICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDLIEKRKFNQNSN
STYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHARQIQVLQRAGAPAEGRP
QPADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQLWTAFLWL
GYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRD
TVECGGQWESQCHPAASSPLVAAQPIDT
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BDBM50436989 |
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n/a |
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Name | BDBM50436989 |
Synonyms: | CHEMBL2402904 |
Type | Small organic molecule |
Emp. Form. | C25H37N5O3 |
Mol. Mass. | 455.593 |
SMILES | COC(=O)N1CCC(CN2CCC(CNC(=O)c3cccc4nc([nH]c34)C(C)C)CC2)CC1 |
Structure |
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