Reaction Details |
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Target | Histone deacetylase 2 |
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Ligand | BDBM50115661 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1541051 (CHEMBL3744282) |
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IC50 | 8230±n/a nM |
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Citation | Zwick, V; Nurisso, A; Simões-Pires, C; Bouchet, S; Martinet, N; Lehotzky, A; Ovadi, J; Cuendet, M; Blanquart, C; Bertrand, P Cross metathesis with hydroxamate and benzamide BOC-protected alkenes to access HDAC inhibitors and their biological evaluation highlighted intrinsic activity of BOC-protected dihydroxamates. Bioorg Med Chem Lett26:154-9 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histone deacetylase 2 |
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Name: | Histone deacetylase 2 |
Synonyms: | Cereblon/Histone deacetylase 2 | HD2 | HDAC2 | HDAC2_HUMAN | Histone deacetylase 2 (HDAC2) | Human HDAC2 |
Type: | Chromatin regulator; hydrolase; repressor |
Mol. Mass.: | 55356.54 |
Organism: | Homo sapiens (Human) |
Description: | Q92769 |
Residue: | 488 |
Sequence: | MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA
TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA
GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH
GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQ
IFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG
GGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYM
EKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEE
FSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGT
KSEQLSNP
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BDBM50115661 |
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n/a |
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Name | BDBM50115661 |
Synonyms: | CHEMBL320497 | N,8-dihydroxy-8-(hydroxyamino)octanamide | N1,N8-dihydroxyoctanediamide | Octanedioic acid bis-hydroxyamide | Suberohydroxamic acid | Suberoic bis hydroxamic acid | Suberoyl bis hydroxamic acid |
Type | Small organic molecule |
Emp. Form. | C8H16N2O4 |
Mol. Mass. | 204.2236 |
SMILES | ONC(=O)CCCCCCC(=O)NO |
Structure |
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