| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dihydrofolate reductase |
|---|
| Ligand | BDBM50049579 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_52843 (CHEMBL665047) |
|---|
| IC50 | 150±n/a nM |
|---|
| Citation |  Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD Nonclassical 2,4-diamino-8-deazafolate analogues as inhibitors of dihydrofolate reductases from rat liver, Pneumocystis carinii, and Toxoplasma gondii. J Med Chem39:1836-45 (1996) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Dihydrofolate reductase |
|---|
| Name: | Dihydrofolate reductase |
|---|
| Synonyms: | DFR1 | DYR_YEAST |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 24263.24 |
|---|
| Organism: | Saccharomyces cerevisiae |
|---|
| Description: | ChEMBL_52843 |
|---|
| Residue: | 211 |
|---|
| Sequence: | MAGGKIPIVGIVACLQPEMGIGFRGGLPWRLPSEMKYFRQVTSLTKDPNKKNALIMGRKT
WESIPPKFRPLPNRMNVIISRSFKDDFVHDKERSIVQSNSLANAIMNLESNFKEHLERIY
VIGGGEVYSQIFSITDHWLITKINPLDKNATPAMDTFLDAKKLEEVFSEQDPAQLKEFLP
PKVELPETDCDQRYSLEEKGYCFEFTLYNRK
|
|
|
|---|
| BDBM50049579 |
|---|
| n/a |
|---|
| Name | BDBM50049579 |
|---|
| Synonyms: | 6-{[(2,5-Dichloro-phenyl)-methyl-amino]-methyl}-pyrido[3,2-d]pyrimidine-2,4-diamine | CHEMBL55191 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H14Cl2N6 |
|---|
| Mol. Mass. | 349.218 |
|---|
| SMILES | CN(Cc1ccc2nc(N)nc(N)c2n1)c1cc(Cl)ccc1Cl |
|---|
| Structure | 
|
|---|
Search and Browse
