Found 150 hits with Last Name = 'francom' and Initial = 'p' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Dihydrofolate reductase
(Rattus norvegicus (rat)) | BDBM18224
(6-[(2,5-dimethoxyphenyl)methyl]-5-methylpyrido[2,3...)Show InChI InChI=1S/C17H19N5O2/c1-9-11(6-10-7-12(23-2)4-5-13(10)24-3)8-20-16-14(9)15(18)21-17(19)22-16/h4-5,7-8H,6H2,1-3H3,(H4,18,19,20,21,22) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Patents
Similars
| MMDB PDB Article PubMed
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibitory activity against rat liver dihydrofolate reductase. |
J Med Chem 39: 1836-45 (1996)
Article DOI: 10.1021/jm950918e BindingDB Entry DOI: 10.7270/Q2319TXB |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Dihydrofolate reductase
(Rattus norvegicus (rat)) | BDBM50049575
(1-{4-[(2,4-Diamino-pyrido[3,2-d]pyrimidin-6-ylmeth...)Show InChI InChI=1S/C16H16N6O/c1-9(23)10-2-4-11(5-3-10)19-8-12-6-7-13-14(20-12)15(17)22-16(18)21-13/h2-7,19H,8H2,1H3,(H4,17,18,21,22) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibitory activity against rat liver dihydrofolate reductase. |
J Med Chem 39: 1836-45 (1996)
Article DOI: 10.1021/jm950918e BindingDB Entry DOI: 10.7270/Q2319TXB |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Rattus norvegicus (rat)) | BDBM50049609
(6-{[(3,4-Dimethoxy-phenyl)-methyl-amino]-methyl}-p...)Show InChI InChI=1S/C17H20N6O2/c1-23(11-5-7-13(24-2)14(8-11)25-3)9-10-4-6-12-15(20-10)16(18)22-17(19)21-12/h4-8H,9H2,1-3H3,(H4,18,19,21,22) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibitory activity against rat liver dihydrofolate reductase. |
J Med Chem 39: 1836-45 (1996)
Article DOI: 10.1021/jm950918e BindingDB Entry DOI: 10.7270/Q2319TXB |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Rattus norvegicus (rat)) | BDBM18268
(5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}...)Show InChI InChI=1S/C19H23N5O3/c1-10-11(5-6-13-16(10)18(20)24-19(21)23-13)9-22-12-7-14(25-2)17(27-4)15(8-12)26-3/h5-8,22H,9H2,1-4H3,(H4,20,21,23,24) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibitory activity against rat liver dihydrofolate reductase. |
J Med Chem 39: 1836-45 (1996)
Article DOI: 10.1021/jm950918e BindingDB Entry DOI: 10.7270/Q2319TXB |
More data for this Ligand-Target Pair | |
Bifunctional dihydrofolate reductase-thymidylate synthase
(Toxoplasma gondii) | BDBM50031867
(6-((methyl(3,4,5-trimethoxyphenyl)amino)methyl)pyr...)Show SMILES COc1cc(cc(OC)c1OC)N(C)Cc1ccc2nc(N)nc(N)c2n1 Show InChI InChI=1S/C18H22N6O3/c1-24(11-7-13(25-2)16(27-4)14(8-11)26-3)9-10-5-6-12-15(21-10)17(19)23-18(20)22-12/h5-8H,9H2,1-4H3,(H4,19,20,22,23) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibitory activity against Toxoplasma gondii dihydrofolate reductase. |
J Med Chem 39: 1836-45 (1996)
Article DOI: 10.1021/jm950918e BindingDB Entry DOI: 10.7270/Q2319TXB |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Rattus norvegicus (rat)) | BDBM50049587
(1-{4-[(2,4-Diamino-pyrido[3,2-d]pyrimidin-6-ylmeth...)Show InChI InChI=1S/C17H18N6O/c1-10(24)11-3-6-13(7-4-11)23(2)9-12-5-8-14-15(20-12)16(18)22-17(19)21-14/h3-8H,9H2,1-2H3,(H4,18,19,21,22) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibitory activity against rat liver dihydrofolate reductase. |
J Med Chem 39: 1836-45 (1996)
Article DOI: 10.1021/jm950918e BindingDB Entry DOI: 10.7270/Q2319TXB |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Rattus norvegicus (rat)) | BDBM50049583
(6-[(Methyl-naphthalen-2-yl-amino)-methyl]-pyrido[3...)Show InChI InChI=1S/C19H18N6/c1-25(15-8-6-12-4-2-3-5-13(12)10-15)11-14-7-9-16-17(22-14)18(20)24-19(21)23-16/h2-10H,11H2,1H3,(H4,20,21,23,24) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibitory activity against rat liver dihydrofolate reductase. |
J Med Chem 39: 1836-45 (1996)
Article DOI: 10.1021/jm950918e BindingDB Entry DOI: 10.7270/Q2319TXB |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Rattus norvegicus (rat)) | BDBM50049604
(6-[(Methyl-naphthalen-1-yl-amino)-methyl]-pyrido[3...)Show InChI InChI=1S/C19H18N6/c1-25(16-8-4-6-12-5-2-3-7-14(12)16)11-13-9-10-15-17(22-13)18(20)24-19(21)23-15/h2-10H,11H2,1H3,(H4,20,21,23,24) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibitory activity against rat liver dihydrofolate reductase. |
J Med Chem 39: 1836-45 (1996)
Article DOI: 10.1021/jm950918e BindingDB Entry DOI: 10.7270/Q2319TXB |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Rattus norvegicus (rat)) | BDBM50049585
(1-{4-[(2,4-Diamino-pyrido[3,2-d]pyrimidin-6-ylmeth...)Show SMILES Nc1nc(N)c2nc(CN(CC#C)c3ccc(cc3)C(=O)C(F)(F)F)ccc2n1 Show InChI InChI=1S/C19H15F3N6O/c1-2-9-28(13-6-3-11(4-7-13)16(29)19(20,21)22)10-12-5-8-14-15(25-12)17(23)27-18(24)26-14/h1,3-8H,9-10H2,(H4,23,24,26,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibitory activity against rat liver dihydrofolate reductase. |
J Med Chem 39: 1836-45 (1996)
Article DOI: 10.1021/jm950918e BindingDB Entry DOI: 10.7270/Q2319TXB |
More data for this Ligand-Target Pair | |
Bifunctional dihydrofolate reductase-thymidylate synthase
(Toxoplasma gondii) | BDBM50049611
(6-[(Methyl-phenyl-amino)-methyl]-pyrido[3,2-d]pyri...)Show InChI InChI=1S/C15H16N6/c1-21(11-5-3-2-4-6-11)9-10-7-8-12-13(18-10)14(16)20-15(17)19-12/h2-8H,9H2,1H3,(H4,16,17,19,20) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibitory activity against Toxoplasma gondii dihydrofolate reductase. |
J Med Chem 39: 1836-45 (1996)
Article DOI: 10.1021/jm950918e BindingDB Entry DOI: 10.7270/Q2319TXB |
More data for this Ligand-Target Pair | |
Bifunctional dihydrofolate reductase-thymidylate synthase
(Toxoplasma gondii) | BDBM50049609
(6-{[(3,4-Dimethoxy-phenyl)-methyl-amino]-methyl}-p...)Show InChI InChI=1S/C17H20N6O2/c1-23(11-5-7-13(24-2)14(8-11)25-3)9-10-4-6-12-15(20-10)16(18)22-17(19)21-12/h4-8H,9H2,1-3H3,(H4,18,19,21,22) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibitory activity against Toxoplasma gondii dihydrofolate reductase. |
J Med Chem 39: 1836-45 (1996)
Article DOI: 10.1021/jm950918e BindingDB Entry DOI: 10.7270/Q2319TXB |
More data for this Ligand-Target Pair | |
Bifunctional dihydrofolate reductase-thymidylate synthase
(Toxoplasma gondii) | BDBM18268
(5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}...)Show InChI InChI=1S/C19H23N5O3/c1-10-11(5-6-13-16(10)18(20)24-19(21)23-13)9-22-12-7-14(25-2)17(27-4)15(8-12)26-3/h5-8,22H,9H2,1-4H3,(H4,20,21,23,24) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibitory activity against Toxoplasma gondii dihydrofolate reductase. |
J Med Chem 39: 1836-45 (1996)
Article DOI: 10.1021/jm950918e BindingDB Entry DOI: 10.7270/Q2319TXB |
More data for this Ligand-Target Pair | |
Bifunctional dihydrofolate reductase-thymidylate synthase
(Toxoplasma gondii) | BDBM50049603
(6-{[(2,4-Dimethoxy-phenyl)-methyl-amino]-methyl}-p...)Show InChI InChI=1S/C17H20N6O2/c1-23(13-7-5-11(24-2)8-14(13)25-3)9-10-4-6-12-15(20-10)16(18)22-17(19)21-12/h4-8H,9H2,1-3H3,(H4,18,19,21,22) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibitory activity against Toxoplasma gondii dihydrofolate reductase. |
J Med Chem 39: 1836-45 (1996)
Article DOI: 10.1021/jm950918e BindingDB Entry DOI: 10.7270/Q2319TXB |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Rattus norvegicus (rat)) | BDBM50049599
(1-{4-[(2,4-Diamino-pyrido[3,2-d]pyrimidin-6-ylmeth...)Show SMILES CC(=O)c1ccc(cc1)N(CC#C)Cc1ccc2nc(N)nc(N)c2n1 Show InChI InChI=1S/C19H18N6O/c1-3-10-25(15-7-4-13(5-8-15)12(2)26)11-14-6-9-16-17(22-14)18(20)24-19(21)23-16/h1,4-9H,10-11H2,2H3,(H4,20,21,23,24) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibitory activity against rat liver dihydrofolate reductase. |
J Med Chem 39: 1836-45 (1996)
Article DOI: 10.1021/jm950918e BindingDB Entry DOI: 10.7270/Q2319TXB |
More data for this Ligand-Target Pair | |
Bifunctional dihydrofolate reductase-thymidylate synthase
(Toxoplasma gondii) | BDBM50049587
(1-{4-[(2,4-Diamino-pyrido[3,2-d]pyrimidin-6-ylmeth...)Show InChI InChI=1S/C17H18N6O/c1-10(24)11-3-6-13(7-4-11)23(2)9-12-5-8-14-15(20-12)16(18)22-17(19)21-14/h3-8H,9H2,1-2H3,(H4,18,19,21,22) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibitory activity against Toxoplasma gondii dihydrofolate reductase. |
J Med Chem 39: 1836-45 (1996)
Article DOI: 10.1021/jm950918e BindingDB Entry DOI: 10.7270/Q2319TXB |
More data for this Ligand-Target Pair | |
Bifunctional dihydrofolate reductase-thymidylate synthase
(Toxoplasma gondii) | BDBM50049607
(6-{[(3-Methoxy-phenyl)-methyl-amino]-methyl}-pyrid...)Show InChI InChI=1S/C16H18N6O/c1-22(11-4-3-5-12(8-11)23-2)9-10-6-7-13-14(19-10)15(17)21-16(18)20-13/h3-8H,9H2,1-2H3,(H4,17,18,20,21) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibitory activity against Toxoplasma gondii dihydrofolate reductase. |
J Med Chem 39: 1836-45 (1996)
Article DOI: 10.1021/jm950918e BindingDB Entry DOI: 10.7270/Q2319TXB |
More data for this Ligand-Target Pair | |
Bifunctional dihydrofolate reductase-thymidylate synthase
(Toxoplasma gondii) | BDBM50049576
(6-{[(2-Chloro-phenyl)-methyl-amino]-methyl}-pyrido...)Show InChI InChI=1S/C15H15ClN6/c1-22(12-5-3-2-4-10(12)16)8-9-6-7-11-13(19-9)14(17)21-15(18)20-11/h2-7H,8H2,1H3,(H4,17,18,20,21) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibitory activity against Toxoplasma gondii dihydrofolate reductase. |
J Med Chem 39: 1836-45 (1996)
Article DOI: 10.1021/jm950918e BindingDB Entry DOI: 10.7270/Q2319TXB |
More data for this Ligand-Target Pair | |
Bifunctional dihydrofolate reductase-thymidylate synthase
(Toxoplasma gondii) | BDBM50049583
(6-[(Methyl-naphthalen-2-yl-amino)-methyl]-pyrido[3...)Show InChI InChI=1S/C19H18N6/c1-25(15-8-6-12-4-2-3-5-13(12)10-15)11-14-7-9-16-17(22-14)18(20)24-19(21)23-16/h2-10H,11H2,1H3,(H4,20,21,23,24) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibitory activity against Toxoplasma gondii dihydrofolate reductase. |
J Med Chem 39: 1836-45 (1996)
Article DOI: 10.1021/jm950918e BindingDB Entry DOI: 10.7270/Q2319TXB |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Rattus norvegicus (rat)) | BDBM50049603
(6-{[(2,4-Dimethoxy-phenyl)-methyl-amino]-methyl}-p...)Show InChI InChI=1S/C17H20N6O2/c1-23(13-7-5-11(24-2)8-14(13)25-3)9-10-4-6-12-15(20-10)16(18)22-17(19)21-12/h4-8H,9H2,1-3H3,(H4,18,19,21,22) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibitory activity against rat liver dihydrofolate reductase. |
J Med Chem 39: 1836-45 (1996)
Article DOI: 10.1021/jm950918e BindingDB Entry DOI: 10.7270/Q2319TXB |
More data for this Ligand-Target Pair | |
Bifunctional dihydrofolate reductase-thymidylate synthase
(Toxoplasma gondii) | BDBM50049601
(6-{[(4-Methoxy-phenyl)-methyl-amino]-methyl}-pyrid...)Show InChI InChI=1S/C16H18N6O/c1-22(11-4-6-12(23-2)7-5-11)9-10-3-8-13-14(19-10)15(17)21-16(18)20-13/h3-8H,9H2,1-2H3,(H4,17,18,20,21) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibitory activity against Toxoplasma gondii dihydrofolate reductase. |
J Med Chem 39: 1836-45 (1996)
Article DOI: 10.1021/jm950918e BindingDB Entry DOI: 10.7270/Q2319TXB |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Rattus norvegicus (rat)) | BDBM50031869
(6-(((3,4-dichlorophenyl)(methyl)amino)methyl)pyrid...)Show InChI InChI=1S/C15H14Cl2N6/c1-23(9-3-4-10(16)11(17)6-9)7-8-2-5-12-13(20-8)14(18)22-15(19)21-12/h2-6H,7H2,1H3,(H4,18,19,21,22) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibitory activity against rat liver dihydrofolate reductase. |
J Med Chem 39: 1836-45 (1996)
Article DOI: 10.1021/jm950918e BindingDB Entry DOI: 10.7270/Q2319TXB |
More data for this Ligand-Target Pair | |
Bifunctional dihydrofolate reductase-thymidylate synthase
(Toxoplasma gondii) | BDBM18224
(6-[(2,5-dimethoxyphenyl)methyl]-5-methylpyrido[2,3...)Show InChI InChI=1S/C17H19N5O2/c1-9-11(6-10-7-12(23-2)4-5-13(10)24-3)8-20-16-14(9)15(18)21-17(19)22-16/h4-5,7-8H,6H2,1-3H3,(H4,18,19,20,21,22) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibitory activity against Toxoplasma gondii dihydrofolate reductase. |
J Med Chem 39: 1836-45 (1996)
Article DOI: 10.1021/jm950918e BindingDB Entry DOI: 10.7270/Q2319TXB |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Rattus norvegicus (rat)) | BDBM50049601
(6-{[(4-Methoxy-phenyl)-methyl-amino]-methyl}-pyrid...)Show InChI InChI=1S/C16H18N6O/c1-22(11-4-6-12(23-2)7-5-11)9-10-3-8-13-14(19-10)15(17)21-16(18)20-13/h3-8H,9H2,1-2H3,(H4,17,18,20,21) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibitory activity against rat liver dihydrofolate reductase. |
J Med Chem 39: 1836-45 (1996)
Article DOI: 10.1021/jm950918e BindingDB Entry DOI: 10.7270/Q2319TXB |
More data for this Ligand-Target Pair | |
Bifunctional dihydrofolate reductase-thymidylate synthase
(Toxoplasma gondii) | BDBM50049604
(6-[(Methyl-naphthalen-1-yl-amino)-methyl]-pyrido[3...)Show InChI InChI=1S/C19H18N6/c1-25(16-8-4-6-12-5-2-3-7-14(12)16)11-13-9-10-15-17(22-13)18(20)24-19(21)23-15/h2-10H,11H2,1H3,(H4,20,21,23,24) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibitory activity against Toxoplasma gondii dihydrofolate reductase. |
J Med Chem 39: 1836-45 (1996)
Article DOI: 10.1021/jm950918e BindingDB Entry DOI: 10.7270/Q2319TXB |
More data for this Ligand-Target Pair | |
Bifunctional dihydrofolate reductase-thymidylate synthase
(Toxoplasma gondii) | BDBM50049599
(1-{4-[(2,4-Diamino-pyrido[3,2-d]pyrimidin-6-ylmeth...)Show SMILES CC(=O)c1ccc(cc1)N(CC#C)Cc1ccc2nc(N)nc(N)c2n1 Show InChI InChI=1S/C19H18N6O/c1-3-10-25(15-7-4-13(5-8-15)12(2)26)11-14-6-9-16-17(22-14)18(20)24-19(21)23-16/h1,4-9H,10-11H2,2H3,(H4,20,21,23,24) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibitory activity against Toxoplasma gondii dihydrofolate reductase. |
J Med Chem 39: 1836-45 (1996)
Article DOI: 10.1021/jm950918e BindingDB Entry DOI: 10.7270/Q2319TXB |
More data for this Ligand-Target Pair | |
Bifunctional dihydrofolate reductase-thymidylate synthase
(Toxoplasma gondii) | BDBM50031866
(6-(((3-chlorophenyl)(methyl)amino)methyl)pyrido[3,...)Show InChI InChI=1S/C15H15ClN6/c1-22(11-4-2-3-9(16)7-11)8-10-5-6-12-13(19-10)14(17)21-15(18)20-12/h2-7H,8H2,1H3,(H4,17,18,20,21) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibitory activity against Toxoplasma gondii dihydrofolate reductase. |
J Med Chem 39: 1836-45 (1996)
Article DOI: 10.1021/jm950918e BindingDB Entry DOI: 10.7270/Q2319TXB |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Rattus norvegicus (rat)) | BDBM50049611
(6-[(Methyl-phenyl-amino)-methyl]-pyrido[3,2-d]pyri...)Show InChI InChI=1S/C15H16N6/c1-21(11-5-3-2-4-6-11)9-10-7-8-12-13(18-10)14(16)20-15(17)19-12/h2-8H,9H2,1H3,(H4,16,17,19,20) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibitory activity against rat liver dihydrofolate reductase. |
J Med Chem 39: 1836-45 (1996)
Article DOI: 10.1021/jm950918e BindingDB Entry DOI: 10.7270/Q2319TXB |
More data for this Ligand-Target Pair | |
Bifunctional dihydrofolate reductase-thymidylate synthase
(Toxoplasma gondii) | BDBM50049613
(6-{[(2,5-Dimethoxy-phenyl)-methyl-amino]-methyl}-p...)Show InChI InChI=1S/C17H20N6O2/c1-23(13-8-11(24-2)5-7-14(13)25-3)9-10-4-6-12-15(20-10)16(18)22-17(19)21-12/h4-8H,9H2,1-3H3,(H4,18,19,21,22) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibitory activity against Toxoplasma gondii dihydrofolate reductase. |
J Med Chem 39: 1836-45 (1996)
Article DOI: 10.1021/jm950918e BindingDB Entry DOI: 10.7270/Q2319TXB |
More data for this Ligand-Target Pair | |
Bifunctional dihydrofolate reductase-thymidylate synthase
(Toxoplasma gondii) | BDBM50049579
(6-{[(2,5-Dichloro-phenyl)-methyl-amino]-methyl}-py...)Show InChI InChI=1S/C15H14Cl2N6/c1-23(12-6-8(16)2-4-10(12)17)7-9-3-5-11-13(20-9)14(18)22-15(19)21-11/h2-6H,7H2,1H3,(H4,18,19,21,22) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibitory activity against Toxoplasma gondii dihydrofolate reductase. |
J Med Chem 39: 1836-45 (1996)
Article DOI: 10.1021/jm950918e BindingDB Entry DOI: 10.7270/Q2319TXB |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Rattus norvegicus (rat)) | BDBM50031867
(6-((methyl(3,4,5-trimethoxyphenyl)amino)methyl)pyr...)Show SMILES COc1cc(cc(OC)c1OC)N(C)Cc1ccc2nc(N)nc(N)c2n1 Show InChI InChI=1S/C18H22N6O3/c1-24(11-7-13(25-2)16(27-4)14(8-11)26-3)9-10-5-6-12-15(21-10)17(19)23-18(20)22-12/h5-8H,9H2,1-4H3,(H4,19,20,22,23) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibitory activity against rat liver dihydrofolate reductase. |
J Med Chem 39: 1836-45 (1996)
Article DOI: 10.1021/jm950918e BindingDB Entry DOI: 10.7270/Q2319TXB |
More data for this Ligand-Target Pair | |
Bifunctional dihydrofolate reductase-thymidylate synthase
(Toxoplasma gondii) | BDBM50049612
(6-{[(2-Methoxy-phenyl)-methyl-amino]-methyl}-pyrid...)Show InChI InChI=1S/C16H18N6O/c1-22(12-5-3-4-6-13(12)23-2)9-10-7-8-11-14(19-10)15(17)21-16(18)20-11/h3-8H,9H2,1-2H3,(H4,17,18,20,21) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibitory activity against Toxoplasma gondii dihydrofolate reductase. |
J Med Chem 39: 1836-45 (1996)
Article DOI: 10.1021/jm950918e BindingDB Entry DOI: 10.7270/Q2319TXB |
More data for this Ligand-Target Pair | |
Bifunctional dihydrofolate reductase-thymidylate synthase
(Toxoplasma gondii) | BDBM50049582
(6-(Naphthalen-1-ylaminomethyl)-pyrido[3,2-d]pyrimi...)Show InChI InChI=1S/C18H16N6/c19-17-16-15(23-18(20)24-17)9-8-12(22-16)10-21-14-7-3-5-11-4-1-2-6-13(11)14/h1-9,21H,10H2,(H4,19,20,23,24) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibitory activity against Toxoplasma gondii dihydrofolate reductase. |
J Med Chem 39: 1836-45 (1996)
Article DOI: 10.1021/jm950918e BindingDB Entry DOI: 10.7270/Q2319TXB |
More data for this Ligand-Target Pair | |
Bifunctional dihydrofolate reductase-thymidylate synthase
(Toxoplasma gondii) | BDBM50031869
(6-(((3,4-dichlorophenyl)(methyl)amino)methyl)pyrid...)Show InChI InChI=1S/C15H14Cl2N6/c1-23(9-3-4-10(16)11(17)6-9)7-8-2-5-12-13(20-8)14(18)22-15(19)21-12/h2-6H,7H2,1H3,(H4,18,19,21,22) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibitory activity against Toxoplasma gondii dihydrofolate reductase. |
J Med Chem 39: 1836-45 (1996)
Article DOI: 10.1021/jm950918e BindingDB Entry DOI: 10.7270/Q2319TXB |
More data for this Ligand-Target Pair | |
Bifunctional dihydrofolate reductase-thymidylate synthase
(Toxoplasma gondii) | BDBM50049575
(1-{4-[(2,4-Diamino-pyrido[3,2-d]pyrimidin-6-ylmeth...)Show InChI InChI=1S/C16H16N6O/c1-9(23)10-2-4-11(5-3-10)19-8-12-6-7-13-14(20-12)15(17)22-16(18)21-13/h2-7,19H,8H2,1H3,(H4,17,18,21,22) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibitory activity against Toxoplasma gondii dihydrofolate reductase. |
J Med Chem 39: 1836-45 (1996)
Article DOI: 10.1021/jm950918e BindingDB Entry DOI: 10.7270/Q2319TXB |
More data for this Ligand-Target Pair | |
Bifunctional dihydrofolate reductase-thymidylate synthase
(Toxoplasma gondii) | BDBM50049608
(6-[(2,6-Dichloro-phenylamino)-methyl]-pyrido[3,2-d...)Show InChI InChI=1S/C14H12Cl2N6/c15-8-2-1-3-9(16)11(8)19-6-7-4-5-10-12(20-7)13(17)22-14(18)21-10/h1-5,19H,6H2,(H4,17,18,21,22) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibitory activity against Toxoplasma gondii dihydrofolate reductase. |
J Med Chem 39: 1836-45 (1996)
Article DOI: 10.1021/jm950918e BindingDB Entry DOI: 10.7270/Q2319TXB |
More data for this Ligand-Target Pair | |
Bifunctional dihydrofolate reductase-thymidylate synthase
(Toxoplasma gondii) | BDBM50049586
(6-{[(2,6-Dichloro-phenyl)-methyl-amino]-methyl}-py...)Show InChI InChI=1S/C15H14Cl2N6/c1-23(13-9(16)3-2-4-10(13)17)7-8-5-6-11-12(20-8)14(18)22-15(19)21-11/h2-6H,7H2,1H3,(H4,18,19,21,22) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibitory activity against Toxoplasma gondii dihydrofolate reductase. |
J Med Chem 39: 1836-45 (1996)
Article DOI: 10.1021/jm950918e BindingDB Entry DOI: 10.7270/Q2319TXB |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Saccharomyces cerevisiae) | BDBM18224
(6-[(2,5-dimethoxyphenyl)methyl]-5-methylpyrido[2,3...)Show InChI InChI=1S/C17H19N5O2/c1-9-11(6-10-7-12(23-2)4-5-13(10)24-3)8-20-16-14(9)15(18)21-17(19)22-16/h4-5,7-8H,6H2,1-3H3,(H4,18,19,20,21,22) | Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibitory activity against Pneumocystis carinii dihydrofolate reductase. |
J Med Chem 39: 1836-45 (1996)
Article DOI: 10.1021/jm950918e BindingDB Entry DOI: 10.7270/Q2319TXB |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Rattus norvegicus (rat)) | BDBM50049590
(1-{4-[(2,4-Diamino-pyrido[3,2-d]pyrimidin-6-ylmeth...)Show SMILES CN(Cc1ccc2nc(N)nc(N)c2n1)c1ccc(cc1)C(=O)C(F)(F)F Show InChI InChI=1S/C17H15F3N6O/c1-26(11-5-2-9(3-6-11)14(27)17(18,19)20)8-10-4-7-12-13(23-10)15(21)25-16(22)24-12/h2-7H,8H2,1H3,(H4,21,22,24,25) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibitory activity against rat liver dihydrofolate reductase. |
J Med Chem 39: 1836-45 (1996)
Article DOI: 10.1021/jm950918e BindingDB Entry DOI: 10.7270/Q2319TXB |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Rattus norvegicus (rat)) | BDBM50049607
(6-{[(3-Methoxy-phenyl)-methyl-amino]-methyl}-pyrid...)Show InChI InChI=1S/C16H18N6O/c1-22(11-4-3-5-12(8-11)23-2)9-10-6-7-13-14(19-10)15(17)21-16(18)20-13/h3-8H,9H2,1-2H3,(H4,17,18,20,21) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibitory activity against rat liver dihydrofolate reductase. |
J Med Chem 39: 1836-45 (1996)
Article DOI: 10.1021/jm950918e BindingDB Entry DOI: 10.7270/Q2319TXB |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Saccharomyces cerevisiae) | BDBM50031869
(6-(((3,4-dichlorophenyl)(methyl)amino)methyl)pyrid...)Show InChI InChI=1S/C15H14Cl2N6/c1-23(9-3-4-10(16)11(17)6-9)7-8-2-5-12-13(20-8)14(18)22-15(19)21-12/h2-6H,7H2,1H3,(H4,18,19,21,22) | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibitory activity against Pneumocystis carinii dihydrofolate reductase. |
J Med Chem 39: 1836-45 (1996)
Article DOI: 10.1021/jm950918e BindingDB Entry DOI: 10.7270/Q2319TXB |
More data for this Ligand-Target Pair | |
Bifunctional dihydrofolate reductase-thymidylate synthase
(Toxoplasma gondii) | BDBM50049588
(6-{[Methyl-(3,4,5-trichloro-phenyl)-amino]-methyl}...)Show SMILES CN(Cc1ccc2nc(N)nc(N)c2n1)c1cc(Cl)c(Cl)c(Cl)c1 Show InChI InChI=1S/C15H13Cl3N6/c1-24(8-4-9(16)12(18)10(17)5-8)6-7-2-3-11-13(21-7)14(19)23-15(20)22-11/h2-5H,6H2,1H3,(H4,19,20,22,23) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibitory activity against Toxoplasma gondii dihydrofolate reductase. |
J Med Chem 39: 1836-45 (1996)
Article DOI: 10.1021/jm950918e BindingDB Entry DOI: 10.7270/Q2319TXB |
More data for this Ligand-Target Pair | |
Bifunctional dihydrofolate reductase-thymidylate synthase
(Toxoplasma gondii) | BDBM50031868
(6-((3,4,5-trimethoxyphenylamino)methyl)pyrido[3,2-...)Show InChI InChI=1S/C17H20N6O3/c1-24-12-6-10(7-13(25-2)15(12)26-3)20-8-9-4-5-11-14(21-9)16(18)23-17(19)22-11/h4-7,20H,8H2,1-3H3,(H4,18,19,22,23) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibitory activity against Toxoplasma gondii dihydrofolate reductase. |
J Med Chem 39: 1836-45 (1996)
Article DOI: 10.1021/jm950918e BindingDB Entry DOI: 10.7270/Q2319TXB |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Rattus norvegicus (rat)) | BDBM50049582
(6-(Naphthalen-1-ylaminomethyl)-pyrido[3,2-d]pyrimi...)Show InChI InChI=1S/C18H16N6/c19-17-16-15(23-18(20)24-17)9-8-12(22-16)10-21-14-7-3-5-11-4-1-2-6-13(11)14/h1-9,21H,10H2,(H4,19,20,23,24) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibitory activity against rat liver dihydrofolate reductase. |
J Med Chem 39: 1836-45 (1996)
Article DOI: 10.1021/jm950918e BindingDB Entry DOI: 10.7270/Q2319TXB |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Saccharomyces cerevisiae) | BDBM50049604
(6-[(Methyl-naphthalen-1-yl-amino)-methyl]-pyrido[3...)Show InChI InChI=1S/C19H18N6/c1-25(16-8-4-6-12-5-2-3-7-14(12)16)11-13-9-10-15-17(22-13)18(20)24-19(21)23-15/h2-10H,11H2,1H3,(H4,20,21,23,24) | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibitory activity against Pneumocystis carinii dihydrofolate reductase. |
J Med Chem 39: 1836-45 (1996)
Article DOI: 10.1021/jm950918e BindingDB Entry DOI: 10.7270/Q2319TXB |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Saccharomyces cerevisiae) | BDBM18268
(5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}...)Show InChI InChI=1S/C19H23N5O3/c1-10-11(5-6-13-16(10)18(20)24-19(21)23-13)9-22-12-7-14(25-2)17(27-4)15(8-12)26-3/h5-8,22H,9H2,1-4H3,(H4,20,21,23,24) | Reactome pathway KEGG
UniProtKB/SwissProt
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CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
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| Article PubMed
| n/a | n/a | 42 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibitory activity against Pneumocystis carinii dihydrofolate reductase. |
J Med Chem 39: 1836-45 (1996)
Article DOI: 10.1021/jm950918e BindingDB Entry DOI: 10.7270/Q2319TXB |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Rattus norvegicus (rat)) | BDBM50049589
(6-[(3,4,5-Trichloro-phenylamino)-methyl]-pyrido[3,...)Show InChI InChI=1S/C14H11Cl3N6/c15-8-3-7(4-9(16)11(8)17)20-5-6-1-2-10-12(21-6)13(18)23-14(19)22-10/h1-4,20H,5H2,(H4,18,19,22,23) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibitory activity against rat liver dihydrofolate reductase. |
J Med Chem 39: 1836-45 (1996)
Article DOI: 10.1021/jm950918e BindingDB Entry DOI: 10.7270/Q2319TXB |
More data for this Ligand-Target Pair | |
Bifunctional dihydrofolate reductase-thymidylate synthase
(Toxoplasma gondii) | BDBM50049591
(6-{[Methyl-(2,4,6-trichloro-phenyl)-amino]-methyl}...)Show SMILES CN(Cc1ccc2nc(N)nc(N)c2n1)c1c(Cl)cc(Cl)cc1Cl Show InChI InChI=1S/C15H13Cl3N6/c1-24(13-9(17)4-7(16)5-10(13)18)6-8-2-3-11-12(21-8)14(19)23-15(20)22-11/h2-5H,6H2,1H3,(H4,19,20,22,23) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibitory activity against Toxoplasma gondii dihydrofolate reductase. |
J Med Chem 39: 1836-45 (1996)
Article DOI: 10.1021/jm950918e BindingDB Entry DOI: 10.7270/Q2319TXB |
More data for this Ligand-Target Pair | |
Bifunctional dihydrofolate reductase-thymidylate synthase
(Toxoplasma gondii) | BDBM50049615
(6-[(2,4,6-Trichloro-phenylamino)-methyl]-pyrido[3,...)Show InChI InChI=1S/C14H11Cl3N6/c15-6-3-8(16)11(9(17)4-6)20-5-7-1-2-10-12(21-7)13(18)23-14(19)22-10/h1-4,20H,5H2,(H4,18,19,22,23) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 46 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibitory activity against Toxoplasma gondii dihydrofolate reductase. |
J Med Chem 39: 1836-45 (1996)
Article DOI: 10.1021/jm950918e BindingDB Entry DOI: 10.7270/Q2319TXB |
More data for this Ligand-Target Pair | |
Bifunctional dihydrofolate reductase-thymidylate synthase
(Toxoplasma gondii) | BDBM50049590
(1-{4-[(2,4-Diamino-pyrido[3,2-d]pyrimidin-6-ylmeth...)Show SMILES CN(Cc1ccc2nc(N)nc(N)c2n1)c1ccc(cc1)C(=O)C(F)(F)F Show InChI InChI=1S/C17H15F3N6O/c1-26(11-5-2-9(3-6-11)14(27)17(18,19)20)8-10-4-7-12-13(23-10)15(21)25-16(22)24-12/h2-7H,8H2,1H3,(H4,21,22,24,25) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 46 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibitory activity against Toxoplasma gondii dihydrofolate reductase. |
J Med Chem 39: 1836-45 (1996)
Article DOI: 10.1021/jm950918e BindingDB Entry DOI: 10.7270/Q2319TXB |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Rattus norvegicus (rat)) | BDBM50049579
(6-{[(2,5-Dichloro-phenyl)-methyl-amino]-methyl}-py...)Show InChI InChI=1S/C15H14Cl2N6/c1-23(12-6-8(16)2-4-10(12)17)7-9-3-5-11-13(20-9)14(18)22-15(19)21-11/h2-6H,7H2,1H3,(H4,18,19,21,22) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 47 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibitory activity against rat liver dihydrofolate reductase. |
J Med Chem 39: 1836-45 (1996)
Article DOI: 10.1021/jm950918e BindingDB Entry DOI: 10.7270/Q2319TXB |
More data for this Ligand-Target Pair | |