| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Prolyl endopeptidase |
|---|
| Ligand | BDBM50051516 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_158381 (CHEMBL769582) |
|---|
| IC50 | 1.4±n/a nM |
|---|
| Citation |  Portevin, B; Benoist, A; Rémond, G; Hervé, Y; Vincent, M; Lepagnol, J; De Nanteuil, G New prolyl endopeptidase inhibitors: in vitro and in vivo activities of azabicyclo[2.2.2]octane, azabicyclo[2.2.1]heptane, and perhydroindole derivatives. J Med Chem39:2379-91 (1996) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Prolyl endopeptidase |
|---|
| Name: | Prolyl endopeptidase |
|---|
| Synonyms: | PPCE_RAT | Prep |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 80731.99 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_1336163 |
|---|
| Residue: | 710 |
|---|
| Sequence: | MLSFQYPDVYRDETSVQDYHGHKICDPYAWLEDPDSEQTKAFVEAQNKITVPFLEQCPIR
GLYKERMTELYDYPKYSCHFKKGKRYFYFYNTGLQNQRVLYVQDSLEGEARVFLDPNTLS
DDGTVALRGYAFSEDGEYFAYGLSASGSDWVTIKFMKVDGAKELPDVLERVKFTCMAWTH
DGKGMFYNSYPQQDGKSDGTETSTNLHQKLCYHVLGTDQSEDVLCAEFPDEPKWMGGAEL
SDDGRYVLLSIWEGCDPVNRLWYCDLQQGSNGINGILKWVKLIDNFEGEYDYITNEGTVF
TFKTNRNSPNYRLINIDFTDPDESKWKVLVPEHEKDVLEWVACVRSNFLVLCYLRNVKNI
LQLHDLTTGALLKTFPLDVGSVVGYSGRKKDSEIFYQFTSFLSPGVIYHCDLTREELEPR
VFREVTVKGIDASDYQTIQVFYPSKDGTKIPMFIVHKKGIKLDGSHPAFLYGYGGFNISI
TPNYSVSRLIFVRHMGGVLAVANIRGGGEYGETWHKGGILANKQNCFDDFQCAAEYLIKE
GYTTSKRLTINGGSNGGLLVAACANQRPDLFGCVIAQVGVMDMLKFHKFTIGHAWTTDYG
CSDSKQHFEWLLKYSPLHNVKLPEADDIQYPSMLLLTADHDDRVVPLHSLKFIATLQYIV
GRSRKQSNPLLIHVDTKAGHGPGKPTAKVIEEVSDMFAFIARCLNIEWIQ
|
|
|
|---|
| BDBM50051516 |
|---|
| n/a |
|---|
| Name | BDBM50051516 |
|---|
| Synonyms: | CHEMBL79213 | [(2S,3aS,7aS)-2-(Pyrrolidine-1-carbonyl)-octahydro-indol-1-yl]-((1R,2S)-2-p-tolyl-cyclopropyl)-methanone |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H32N2O2 |
|---|
| Mol. Mass. | 380.5231 |
|---|
| SMILES | Cc1ccc(cc1)[C@H]1C[C@H]1C(=O)N1[C@H]2CCCC[C@H]2C[C@H]1C(=O)N1CCCC1 |
|---|
| Structure | 
|
|---|
Search and Browse
