| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Muscarinic acetylcholine receptor M2 |
|---|
| Ligand | BDBM50502367 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1807452 (CHEMBL4306811) |
|---|
| EC50 | >8830±n/a nM |
|---|
| Citation |  Yang, Q; Lachapelle, EA; Kablaoui, NM; Webb, D; Popiolek, M; Grimwood, S; Kozak, R; O'Connor, RE; Lazzaro, JT; Butler, CR; Zhang, L Discovery of Selective M4 Muscarinic Acetylcholine Receptor Agonists with Novel Carbamate Isosteres. ACS Med Chem Lett10:941-948 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Muscarinic acetylcholine receptor M2 |
|---|
| Name: | Muscarinic acetylcholine receptor M2 |
|---|
| Synonyms: | ACM2_HUMAN | CHRM2 | Cholinergic, muscarinic M2 | Muscarinic acetylcholine receptor M2 and M4 | Muscarinic acetylcholine receptor M2 and M5 | RecName: Full=Muscarinic acetylcholine receptor M2 |
|---|
| Type: | GPCR |
|---|
| Mol. Mass.: | 51730.61 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P08172 |
|---|
| Residue: | 466 |
|---|
| Sequence: | MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY
FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD
RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF
FSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRI
VKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDE
ITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNI
VARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNT
VWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
|
|
|
|---|
| BDBM50502367 |
|---|
| n/a |
|---|
| Name | BDBM50502367 |
|---|
| Synonyms: | CHEMBL4524686 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H29N5O |
|---|
| Mol. Mass. | 367.4879 |
|---|
| SMILES | COc1cccnc1C1CCN(CC2CCN(CC2)c2cnccn2)CC1 |
|---|
| Structure | 
|
|---|
Search and Browse
