Reaction Details |
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Target | Muscarinic acetylcholine receptor M4 |
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Ligand | BDBM50502368 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1807451 (CHEMBL4306810) |
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EC50 | >10000±n/a nM |
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Citation | Yang, Q; Lachapelle, EA; Kablaoui, NM; Webb, D; Popiolek, M; Grimwood, S; Kozak, R; O'Connor, RE; Lazzaro, JT; Butler, CR; Zhang, L Discovery of Selective M4 Muscarinic Acetylcholine Receptor Agonists with Novel Carbamate Isosteres. ACS Med Chem Lett10:941-948 (2019) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Muscarinic acetylcholine receptor M4 |
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Name: | Muscarinic acetylcholine receptor M4 |
Synonyms: | ACM4_HUMAN | CHRM4 | Cholinergic, muscarinic M4 | Muscarinic acetylcholine receptor | Muscarinic acetylcholine receptor M2 and M4 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 53079.31 |
Organism: | Homo sapiens (Human) |
Description: | Cholinergic, muscarinic M4 CHRM4 HUMAN M3::P08173 |
Residue: | 479 |
Sequence: | MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVN
RQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASV
MNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTV
PDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAK
TLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGS
ATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIV
PATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMV
LVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
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BDBM50502368 |
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n/a |
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Name | BDBM50502368 |
Synonyms: | CHEMBL4447576 |
Type | Small organic molecule |
Emp. Form. | C21H29N5O |
Mol. Mass. | 367.4879 |
SMILES | COc1cccnc1C1CCN(CC1)C1CCCN(CC1)c1cccnn1 |
Structure |
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