| Reaction Details |
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 | Report a problem with these data |
| Target | Acetylcholinesterase |
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| Ligand | BDBM50052409 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_27788 (CHEMBL637615) |
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| IC50 | 759±n/a nM |
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| Citation |  Pool, WF; Woolf, TF; Reily, MD; Caprathe, BW; Emmerling, MR; Jaen, JC Identification of a 3-hydroxylated tacrine metabolite in rat and man: metabolic profiling implications and pharmacology. J Med Chem39:3014-8 (1996) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Acetylcholinesterase |
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| Name: | Acetylcholinesterase |
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| Synonyms: | ACES_HUMAN | ACHE | Acetylcholinesterase (AChE) | Acetylcholinesterase (human AChE) |
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| Type: | Enzyme |
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| Mol. Mass.: | 67792.70 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P22303 |
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| Residue: | 614 |
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| Sequence: | MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPV
SAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPN
RELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSM
NYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASV
GMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTEL
VACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVG
VVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPE
DPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGY
EIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQ
YVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKN
QFDHYSKQDRCSDL
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| BDBM50052409 |
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| n/a |
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| Name | BDBM50052409 |
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| Synonyms: | 7-Hydroxytacrine | 9-Amino-1,2,3,4-tetrahydro-acridin-3-ol | CHEMBL1127 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H14N2O |
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| Mol. Mass. | 214.2631 |
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| SMILES | Nc1c2CCC(O)Cc2nc2ccccc12 |
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| Structure | 
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