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TargetProtein-S-isoprenylcysteine O-methyltransferase
LigandBDBM50502487
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1807706 (CHEMBL4307065)
IC50 0.900000±n/a nM
Citation Kargbo, RB Treatment of Cancers by Inhibition of Isoprenylcysteine Carboxyl Methyltransferase. ACS Med Chem Lett10:1024-1025 (2019) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Protein-S-isoprenylcysteine O-methyltransferase
Name:Protein-S-isoprenylcysteine O-methyltransferase
Synonyms:ICMT | ICMT_HUMAN | Isoprenylcysteine carboxyl methyltransferase | PCCMT
Type:PROTEIN
Mol. Mass.:31943.26
Organism:Homo sapiens (Human)
Description:ChEMBL_956034
Residue:284
Sequence:
MAGCAARAPPGSEARLSLATFLLGASVLALPLLTRAGLQGRTGLALYVAGLNALLLLLYR
PPRYQIAIRACFLGFVFGCGTLLSFSQSSWSHFGWYMCSLSLFHYSEYLVTAVNNPKSLS
LDSFLLNHSLEYTVAALSSWLEFTLENIFWPELKQITWLSVTGLLMVVFGECLRKAAMFT
AGSNFNHVVQNEKSDTHTLVTSGVYAWFRHPSYVGWFYWSIGTQVMLCNPICGVSYALTV
WRFFRDRTEEEEISLIHFFGEEYLEYKKRVPTGLPFIKGVKVDL
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BDBM50502487
n/a
NameBDBM50502487
Synonyms:CHEMBL4473893 | US11834430, Compound 15
TypeSmall organic molecule
Emp. Form.C20H19N3O3
Mol. Mass.349.3832
SMILESCOc1cc(ccc1OCCOc1cccc(c1)-c1ccnn1C)C#N
Structure
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