| Reaction Details |
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 | Report a problem with these data |
| Target | Platelet-activating factor acetylhydrolase |
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| Ligand | BDBM50503339 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1810391 (CHEMBL4309851) |
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| IC50 | 93±n/a nM |
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| Citation |  Cisar, JS; Weber, OD; Clapper, JR; Blankman, JL; Henry, CL; Simon, GM; Alexander, JP; Jones, TK; Ezekowitz, RAB; O'Neill, GP; Grice, CA Identification of ABX-1431, a Selective Inhibitor of Monoacylglycerol Lipase and Clinical Candidate for Treatment of Neurological Disorders. J Med Chem61:9062-9084 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Platelet-activating factor acetylhydrolase |
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| Name: | Platelet-activating factor acetylhydrolase |
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| Synonyms: | 1-alkyl-2-acetylglycerophosphocholine esterase | 2-acetyl-1-alkylglycerophosphocholine esterase | LDL-PLA(2) | LDL-associated phospholipase A2 | PAF 2-acylhydrolase | PAF acetylhydrolase | PAFAH | PAFA_HUMAN | PLA2G7 | Platelet-activating factor acetylhydrolase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 50084.41 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_156212 |
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| Residue: | 441 |
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| Sequence: | MVPPKLHVLFCLCGCLAVVYPFDWQYINPVAHMKSSAWVNKIQVLMAAASFGQTKIPRGN
GPYSVGCTDLMFDHTNKGTFLRLYYPSQDNDRLDTLWIPNKEYFWGLSKFLGTHWLMGNI
LRLLFGSMTTPANWNSPLRPGEKYPLVVFSHGLGAFRTLYSAIGIDLASHGFIVAAVEHR
DRSASATYYFKDQSAAEIGDKSWLYLRTLKQEEETHIRNEQVRQRAKECSQALSLILDID
HGKPVKNALDLKFDMEQLKDSIDREKIAVIGHSFGGATVIQTLSEDQRFRCGIALDAWMF
PLGDEVYSRIPQPLFFINSEYFQYPANIIKMKKCYSPDKERKMITIRGSVHQNFADFTFA
TGKIIGHMLKLKGDIDSNVAIDLSNKASLAFLQKHLGLHKDFDQWDCLIEGDDENLIPGT
NINTTNQHIMLQNSSGIEKYN
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| BDBM50503339 |
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| n/a |
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| Name | BDBM50503339 |
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| Synonyms: | CHEMBL4469632 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H24F6N6O2 |
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| Mol. Mass. | 554.4875 |
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| SMILES | Cn1ncc2cc(ccc12)C(N1CCN(CC1)C(=O)OC(C(F)(F)F)C(F)(F)F)c1ccc2n(C)ncc2c1 |
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| Structure | 
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