Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetMonoacylglycerol lipase ABHD6
LigandBDBM180076
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1810390 (CHEMBL4309850)
IC50 130±n/a nM
Citation Cisar, JSWeber, ODClapper, JRBlankman, JLHenry, CLSimon, GMAlexander, JPJones, TKEzekowitz, RABO'Neill, GPGrice, CA Identification of ABX-1431, a Selective Inhibitor of Monoacylglycerol Lipase and Clinical Candidate for Treatment of Neurological Disorders. J Med Chem61:9062-9084 (2018) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Monoacylglycerol lipase ABHD6
Name:Monoacylglycerol lipase ABHD6
Synonyms:2-arachidonoylglycerol hydrolase | ABHD6 | ABHD6_HUMAN | Abhydrolase domain-containing protein 6 | Monoacylglycerol lipase ABHD6
Type:PROTEIN
Mol. Mass.:38341.83
Organism:Homo sapiens (Human)
Description:ChEMBL_105457
Residue:337
Sequence:
MDLDVVNMFVIAGGTLAIPILAFVASFLLWPSALIRIYYWYWRRTLGMQVRYVHHEDYQF
CYSFRGRPGHKPSILMLHGFSAHKDMWLSVVKFLPKNLHLVCVDMPGHEGTTRSSLDDLS
IDGQVKRIHQFVECLKLNKKPFHLVGTSMGGQVAGVYAAYYPSDVSSLCLVCPAGLQYST
DNQFVQRLKELQGSAAVEKIPLIPSTPEEMSEMLQLCSYVRFKVPQQILQGLVDVRIPHN
NFYRKLFLEIVSEKSRYSLHQNMDKIKVPTQIIWGKQDQVLDVSGADMLAKSIANCQVEL
LENCGHSVVMERPRKTAKLIIDFLASVHNTDNNKKLD
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM180076
n/a
NameBDBM180076
Synonyms:US9133148, 10e
TypeSmall organic molecule
Emp. Form.C19H20F6N4O2
Mol. Mass.450.3781
SMILESCn1cc(CN2CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F)c(n1)-c1ccccc1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: