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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | 5-hydroxytryptamine receptor 1A | ||
| Ligand | BDBM50443101 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1814788 (CHEMBL4314362) | ||
| Ki | 2.6±n/a nM | ||
| Citation |  Wróbel, MZ; Chodkowski, A; Herold, F; Marciniak, M; Dawidowski, M; Siwek, A; Starowicz, G; Stachowicz, K; Szewczyk, B; Nowak, G; Belka, M; B?czek, T; Sata?a, G; Bojarski, AJ; Tur?o, J Synthesis and biological evaluation of new multi-target 3-(1H-indol-3-yl)pyrrolidine-2,5-dione derivatives with potential antidepressant effect. Eur J Med Chem183:0 (2019) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| 5-hydroxytryptamine receptor 1A | |||
| Name: | 5-hydroxytryptamine receptor 1A | ||
| Synonyms: | 5-HT-1A | 5-HT1A | 5-hydroxytryptamine receptor 1A (5-HT-1A) | 5HT1A_HUMAN | ADRB2RL1 | ADRBRL1 | Dopamine D2 receptor and serotonin 1a receptor | G-21 | HTR1A | Serotonin receptor 1A | ||
| Type: | n/a | ||
| Mol. Mass.: | 46122.49 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | n/a | ||
| Residue: | 422 | ||
| Sequence: |
| ||
| BDBM50443101 | |||
| n/a | |||
| Name | BDBM50443101 | ||
| Synonyms: | Cariprazine | RGH-188 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H32Cl2N4O | ||
| Mol. Mass. | 427.411 | ||
| SMILES | CN(C)C(=O)N[C@H]1CC[C@H](CCN2CCN(CC2)c2cccc(Cl)c2Cl)CC1 |r,wU:6.5,wD:9.9,(-.77,5.69,;.57,4.92,;1.9,5.69,;.57,3.38,;-.77,2.61,;1.9,2.61,;1.9,1.07,;3.23,.3,;3.23,-1.24,;1.9,-2.01,;1.9,-3.55,;3.23,-4.32,;3.23,-5.86,;4.57,-6.63,;4.57,-8.17,;3.23,-8.94,;1.9,-8.17,;1.9,-6.63,;3.23,-10.48,;4.57,-11.25,;4.57,-12.79,;3.23,-13.56,;1.9,-12.79,;.57,-13.56,;1.9,-11.25,;.57,-10.48,;.57,-1.24,;.57,.3,)| | ||
| Structure | 
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