| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Carbonic anhydrase 2 |
|---|
| Ligand | BDBM50504773 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1816575 (CHEMBL4316149) |
|---|
| Ki | 8.9±n/a nM |
|---|
| Citation |  Said, MA; Eldehna, WM; Nocentini, A; Bonardi, A; Fahim, SH; Bua, S; Soliman, DH; Abdel-Aziz, HA; Gratteri, P; Abou-Seri, SM; Supuran, CT Synthesis, biological and molecular dynamics investigations with a series of triazolopyrimidine/triazole-based benzenesulfonamides as novel carbonic anhydrase inhibitors. Eur J Med Chem185:0 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Carbonic anhydrase 2 |
|---|
| Name: | Carbonic anhydrase 2 |
|---|
| Synonyms: | CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 29250.71 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P00918 |
|---|
| Residue: | 260 |
|---|
| Sequence: | MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRIL
NNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHL
VHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDP
RGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELM
VDNWRPAQPLKNRQIKASFK
|
|
|
|---|
| BDBM50504773 |
|---|
| n/a |
|---|
| Name | BDBM50504773 |
|---|
| Synonyms: | CHEMBL4520887 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H17N7O3S |
|---|
| Mol. Mass. | 399.427 |
|---|
| SMILES | C\C(=N/NC(=O)c1nc(N)n(n1)-c1ccc(cc1)S(N)(=O)=O)c1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
