| Reaction Details |
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 | Report a problem with these data |
| Target | NT-3 growth factor receptor |
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| Ligand | BDBM50505012 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1816967 (CHEMBL4316541) |
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| EC50 | 330±n/a nM |
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| Citation |  Kargbo, RB Modulation of Tropomyosin Receptor Kinase for the Treatment of Neurotrophin Diseases: Alzheimer's, Huntington's and Parkinson's. ACS Med Chem Lett10:1590-1591 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| NT-3 growth factor receptor |
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| Name: | NT-3 growth factor receptor |
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| Synonyms: | GP145-TrkC | NTRK3 | NTRK3_HUMAN | Neurotrophic tyrosine kinase receptor | Neurotrophic tyrosine kinase receptor type 3 | TRKC | Trk-C | TrkC tyrosine kinase | Tyrosine kinase receptor C (Trk-C) |
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| Type: | Enzyme |
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| Mol. Mass.: | 94428.15 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16288 |
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| Residue: | 839 |
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| Sequence: | MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQ
DSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQP
RAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEA
KLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPD
VDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALT
VYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISE
GCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPIT
VTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASP
LHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVL
KRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHI
VKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIA
SQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDF
CIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVI
ECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG
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| BDBM50505012 |
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| n/a |
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| Name | BDBM50505012 |
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| Synonyms: | CHEMBL4472787 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H21N3O5 |
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| Mol. Mass. | 431.4406 |
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| SMILES | CC(C)Oc1cc(ccc1Oc1ccccc1)-n1c(=O)[nH]c(=O)n(-c2ccccc2)c1=O |
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| Structure | 
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