Reaction Details |
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Target | Sodium-dependent dopamine transporter |
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Ligand | BDBM50056579 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_61846 (CHEMBL670183) |
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IC50 | 14±n/a nM |
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Citation | Matecka, D; Lewis, D; Rothman, RB; Dersch, CM; Wojnicki, FH; Glowa, JR; DeVries, AC; Pert, A; Rice, KC Heteroaromatic analogs of 1-[2-(diphenylmethoxy)ethyl]- and 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909) as high-affinity dopamine reuptake inhibitors. J Med Chem40:705-16 (1997) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sodium-dependent dopamine transporter |
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Name: | Sodium-dependent dopamine transporter |
Synonyms: | DA transporter | Monoamine transporters; Norepininephrine & dopamine | SC6A3_RAT | Slc6a3 | Sodium-dependent dopamine transporter | Sodium-dependent dopamine transporter (DAT) |
Type: | Multi-pass membrane protein |
Mol. Mass.: | 68749.45 |
Organism: | Rattus norvegicus (rat) |
Description: | P23977 |
Residue: | 619 |
Sequence: | MSKSKCSVGPMSSVVAPAKESNAVGPREVELILVKEQNGVQLTNSTLINPPQTPVEAQER
ETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELAL
GQFNREGAAGVWKICPVLKGVGFTVILISFYVGFFYNVIIAWALHYFFSSFTMDLPWIHC
NNTWNSPNCSDAHASNSSDGLGLNDTFGTTPAAEYFERGVLHLHQSRGIDDLGPPRWQLT
ACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAMDGIRAYLSVD
FYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLTSFSSG
FVVFSFLGYMAQKHNVPIRDVATDGPGLIFIIYPEAIATLPLSSAWAAVFFLMLLTLGID
SAMGGMESVITGLVDEFQLLHRHRELFTLGIVLATFLLSLFCVTNGGIYVFTLLDHFAAG
TSILFGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVVSIV
TFRPPHYGAYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPGSFREKLAYAITPEKDH
QLVDRGEVRQFTLRHWLLL
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BDBM50056579 |
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n/a |
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Name | BDBM50056579 |
Synonyms: | 1-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-4-((E)-3-pyridin-3-yl-allyl)-piperazine | CHEMBL164037 |
Type | Small organic molecule |
Emp. Form. | C27H29F2N3O |
Mol. Mass. | 449.5355 |
SMILES | Fc1ccc(cc1)C(OCCN1CCN(C\C=C\c2cccnc2)CC1)c1ccc(F)cc1 |
Structure |
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