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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Dual specificity protein kinase CLK1 | ||
| Ligand | BDBM50505741 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1823776 (CHEMBL4323540) | ||
| IC50 | 1700±n/a nM | ||
| Citation |  Degorce, SL; Anjum, R; Bloecher, A; Carbajo, RJ; Dillman, KS; Drew, L; Halsall, CT; Lenz, EM; Lindsay, NA; Mayo, MF; Pink, JH; Robb, GR; Rosen, A; Scott, JS; Xue, Y Discovery of a Series of 5-Azaquinazolines as Orally Efficacious IRAK4 Inhibitors Targeting MyD88 J Med Chem62:9918-9930 (2019) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Dual specificity protein kinase CLK1 | |||
| Name: | Dual specificity protein kinase CLK1 | ||
| Synonyms: | CDC-like kinase 1 | CDC-like kinase 1 (CLK1) | CDC2-like kinase 1 (CLK1) | CLK | CLK1 | CLK1_HUMAN | Dual specificity protein kinase CLK1 | Dual specificity protein kinase CLK1/CLK4 | Dual specificty protein kinase CLK1 | ||
| Type: | Protein | ||
| Mol. Mass.: | 57322.21 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P49759 | ||
| Residue: | 484 | ||
| Sequence: |
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| BDBM50505741 | |||
| n/a | |||
| Name | BDBM50505741 | ||
| Synonyms: | CHEMBL4455718 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H26N6O2 | ||
| Mol. Mass. | 394.4701 | ||
| SMILES | COC(=O)N1CCN(CC1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N |r,wU:13.17,wD:10.10,(55.44,-8.62,;55.46,-7.09,;54.13,-6.3,;54.15,-4.76,;52.79,-7.06,;52.77,-8.6,;51.44,-9.36,;50.12,-8.58,;50.12,-7.04,;51.46,-6.28,;48.78,-9.33,;47.44,-8.56,;46.1,-9.32,;46.11,-10.85,;47.43,-11.64,;48.77,-10.87,;44.77,-11.63,;44.77,-13.17,;46.1,-13.94,;46.1,-15.48,;44.77,-16.25,;43.44,-15.48,;42.12,-16.26,;40.78,-15.51,;40.76,-13.96,;42.09,-13.18,;43.43,-13.94,;39.43,-13.22,;38.09,-12.47,)| | ||
| Structure | 
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