Reaction Details |
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Target | NACHT, LRR and PYD domains-containing protein 3 |
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Ligand | BDBM50505855 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1824386 (CHEMBL4324150) |
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IC50 | 42±n/a nM |
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Citation | Zhang, X; Xu, A; Lv, J; Zhang, Q; Ran, Y; Wei, C; Wu, J Development of small molecule inhibitors targeting NLRP3 inflammasome pathway for inflammatory diseases. Eur J Med Chem185:0 (2020) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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NACHT, LRR and PYD domains-containing protein 3 |
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Name: | NACHT, LRR and PYD domains-containing protein 3 |
Synonyms: | Cias1 | Cias1 | Cold autoinflammatory syndrome 1 protein homolog | Cryopyrin | Mast cell maturation-associated-inducible protein 1 | Mmig1 | NACHT, LRR and PYD domains-containing protein 3 | NLRP3_MOUSE | Nalp3 | Nlrp3 | PYRIN-containing APAF1-like protein 1 | Pypaf1 |
Type: | PROTEIN |
Mol. Mass.: | 118281.75 |
Organism: | Mus musculus |
Description: | ChEMBL_116758 |
Residue: | 1033 |
Sequence: | MTSVRCKLAQYLEDLEDVDLKKFKMHLEDYPPEKGCIPVPRGQMEKADHLDLATLMIDFN
GEEKAWAMAVWIFAAINRRDLWEKAKKDQPEWNDTCTSHSSMVCQEDSLEEEWMGLLGYL
SRISICKKKKDYCKMYRRHVRSRFYSIKDRNARLGESVDLNSRYTQLQLVKEHPSKQERE
HELLTIGRTKMRDSPMSSLKLELLFEPEDGHSEPVHTVVFQGAAGIGKTILARKIMLDWA
LGKLFKDKFDYLFFIHCREVSLRTPRSLADLIVSCWPDPNPPVCKILRKPSRILFLMDGF
DELQGAFDEHIGEVCTDWQKAVRGDILLSSLIRKKLLPKASLLITTRPVALEKLQHLLDH
PRHVEILGFSEAKRKEYFFKYFSNELQAREAFRLIQENEVLFTMCFIPLVCWIVCTGLKQ
QMETGKSLAQTSKTTTAVYVFFLSSLLQSRGGIEEHLFSDYLQGLCSLAADGIWNQKILF
EECDLRKHGLQKTDVSAFLRMNVFQKEVDCERFYSFSHMTFQEFFAAMYYLLEEEAEGET
VRKGPGGCSDLLNRDVKVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQ
QVRLELLKWIEVKAKAKKLQWQPSQLELFYCLYEMQEEDFVQSAMDHFPKIEINLSTRMD
HVVSSFCIKNCHRVKTLSLGFFHNSPKEEEEERRGGRPLDQVQCVFPDTHVACSSRLVNC
CLTSSFCRGLFSSLSTNRSLTELDLSDNTLGDPGMRVLCEALQHPGCNIQRLWLGRCGLS
HQCCFDISSVLSSSQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLQKLWLVSCCLTSAC
CQDLALVLSSNHSLTRLYIGENALGDSGVQVLCEKMKDPQCNLQKLGLVNSGLTSICCSA
LTSVLKTNQNFTHLYLRSNALGDTGLRLLCEGLLHPDCKLQMLELDNCSLTSHSCWNLST
ILTHNHSLRKLNLGNNDLGDLCVVTLCEVLKQQGCLLQSLQLGEMYLNRETKRALEALQE
EKPELTIVFEISW
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BDBM50505855 |
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n/a |
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Name | BDBM50505855 |
Synonyms: | CHEMBL4468698 |
Type | Small organic molecule |
Emp. Form. | C29H34N4O5S |
Mol. Mass. | 550.669 |
SMILES | CCC1=C(C)CN(C(=O)NCCc2ccc(cc2)S(=O)(=O)NC(=O)Nc2c3CCCc3cc3CCCc23)C1=O |c:2| |
Structure |
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