| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cytochrome P450 3A5 |
|---|
| Ligand | BDBM39347 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1825914 (CHEMBL4325678) |
|---|
| IC50 | 78±n/a nM |
|---|
| Citation |  Wright, WC; Chenge, J; Wang, J; Girvan, HM; Yang, L; Chai, SC; Huber, AD; Wu, J; Oladimeji, PO; Munro, AW; Chen, T Clobetasol Propionate Is a Heme-Mediated Selective Inhibitor of Human Cytochrome P450 3A5. J Med Chem63:1415-1433 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cytochrome P450 3A5 |
|---|
| Name: | Cytochrome P450 3A5 |
|---|
| Synonyms: | CP3A5_HUMAN | CYP3A5 | Cytochrome P450 3A5 | Cytochrome P450 3A5 (CYP3A5) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 57118.00 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P20815 |
|---|
| Residue: | 502 |
|---|
| Sequence: | MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKF
DTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISL
AEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYS
MDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSL
FPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSI
IFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVV
NETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFS
KKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQG
LLQPEKPIVLKVDSRDGTLSGE
|
|
|
|---|
| BDBM39347 |
|---|
| n/a |
|---|
| Name | BDBM39347 |
|---|
| Synonyms: | CLOBETASOL PROPIONATE | MLS000028708 | SMR000058745 | cid_32798 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H32ClFO5 |
|---|
| Mol. Mass. | 466.97 |
|---|
| SMILES | CCC(=O)O[C@@]1([C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C)C(=O)CCl |c:17,t:13| |
|---|
| Structure | 
|
|---|
Search and Browse
