| Reaction Details |
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 | Report a problem with these data |
| Target | Squalene synthase |
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| Ligand | BDBM50058949 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_202104 (CHEMBL814213) |
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| IC50 | 180±n/a nM |
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| Citation |  Fung, AK; Baker, WR; Fakhoury, S; Stein, HH; Cohen, J; Donner, BG; Garvey, DS; Spina, KP; Rosenberg, SH (1 alpha, 2 beta, 3 beta, 4 alpha)-1,2-bis[N-propyl-N-(4-phenoxybenzyl) amino]carbonyl]cyclobutane-3,4-dicarboxylic acid (A-87049): a novel potent squalene synthase inhibitor. J Med Chem40:2123-5 (1997) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Squalene synthase |
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| Name: | Squalene synthase |
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| Synonyms: | FDFT_RAT | FPP:FPP farnesyltransferase | Farnesyl-diphosphate farnesyltransferase | Fdft1 | SQS | SS | Squalene synthetase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 48109.41 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1336736 |
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| Residue: | 416 |
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| Sequence: | MEFVKCLGHPEEFYNLLRFRMGGRRNFIPKMDRNSLSNSLKTCYKYLDQTSRSFAAVIQA
LDGDIRHAVCVFYLILRAMDTVEDDMAISVEKKIPLLRNFHTFLYEPEWRFTESKEKHRV
VLEDFPTISLEFRNLAEKYQTVIADICHRMGCGMAEFLNKDVTSKQDWDKYCHYVAGLVG
IGLSRLFSASEFEDPIVGEDTECANSMGLFLQKTNIIRDYLEDQQEGRQFWPQEVWGKYV
KKLEDFVKPENVDVAVKCLNELITNALQHIPDVITYLSRLRNQSVFNFCAIPQVMAIATL
AACYNNHQVFKGVVKIRKGQAVTLMMDATNMPAVKAIIYQYIEEIYHRVPNSDPSASKAK
QLISNIRTQSLPNCQLISRSHYSPIYLSFIMLLAALSWQYLSTLSQVTEDYVQREH
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| BDBM50058949 |
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| n/a |
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| Name | BDBM50058949 |
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| Synonyms: | (1S,2S,3S,4S)-3,4-Bis-[ethyl-(4-phenoxy-benzyl)-carbamoyl]-cyclobutane-1,2-dicarboxylic acid | CHEMBL306441 |
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| Type | Small organic molecule |
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| Emp. Form. | C38H38N2O8 |
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| Mol. Mass. | 650.7169 |
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| SMILES | CCN(Cc1ccc(Oc2ccccc2)cc1)C(=O)[C@@H]1[C@@H]([C@H]([C@H]1C(=O)N(CC)Cc1ccc(Oc2ccccc2)cc1)C(O)=O)C(O)=O |
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| Structure | 
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