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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Polymerase basic protein 2 | ||
| Ligand | BDBM50507233 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1829449 (CHEMBL4329323) | ||
| EC50 | 190±n/a nM | ||
| Citation |  Xiong, J; Wang, J; Hu, G; Zhao, W; Li, J Design, synthesis and biological evaluation of novel, orally bioavailable pyrimidine-fused heterocycles as influenza PB2 inhibitors. Eur J Med Chem162:249-265 (2019) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Polymerase basic protein 2 | |||
| Name: | Polymerase basic protein 2 | ||
| Synonyms: | PB2 | PB2_I34A1 | Polymerase basic protein 2 | RNA-directed RNA polymerase subunit P3 | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 86120.80 | ||
| Organism: | Influenza A virus (strain A/Puerto Rico/8/1934 H1N1) | ||
| Description: | ChEMBL_109460 | ||
| Residue: | 759 | ||
| Sequence: |
| ||
| BDBM50507233 | |||
| n/a | |||
| Name | BDBM50507233 | ||
| Synonyms: | CHEMBL4589525 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H19FN6O2 | ||
| Mol. Mass. | 406.413 | ||
| SMILES | OC(=O)[C@H]1C2CCC(CC2)[C@@H]1n1cnc2cnc(nc12)-c1c[nH]c2ncc(F)cc12 |r,wU:3.2,wD:10.12,(40.52,-2.61,;41.86,-3.37,;43.19,-2.59,;41.87,-4.91,;43.21,-5.68,;43.22,-7.22,;41.89,-7.99,;40.56,-7.24,;41.32,-5.95,;42.44,-6.85,;40.56,-5.69,;39.25,-4.93,;38.21,-3.8,;36.8,-4.43,;36.98,-5.96,;35.95,-7.12,;36.43,-8.58,;37.93,-8.89,;38.97,-7.74,;38.48,-6.27,;38.42,-10.34,;37.52,-11.59,;38.43,-12.84,;39.89,-12.35,;41.22,-13.12,;42.56,-12.35,;42.55,-10.8,;43.88,-10.03,;41.22,-10.04,;39.88,-10.81,)| | ||
| Structure | 
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