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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Polymerase basic protein 2 | ||
| Ligand | BDBM50507238 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1829449 (CHEMBL4329323) | ||
| EC50 | 12±n/a nM | ||
| Citation |  Xiong, J; Wang, J; Hu, G; Zhao, W; Li, J Design, synthesis and biological evaluation of novel, orally bioavailable pyrimidine-fused heterocycles as influenza PB2 inhibitors. Eur J Med Chem162:249-265 (2019) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Polymerase basic protein 2 | |||
| Name: | Polymerase basic protein 2 | ||
| Synonyms: | PB2 | PB2_I34A1 | Polymerase basic protein 2 | RNA-directed RNA polymerase subunit P3 | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 86120.80 | ||
| Organism: | Influenza A virus (strain A/Puerto Rico/8/1934 H1N1) | ||
| Description: | ChEMBL_109460 | ||
| Residue: | 759 | ||
| Sequence: |
| ||
| BDBM50507238 | |||
| n/a | |||
| Name | BDBM50507238 | ||
| Synonyms: | CHEMBL4527175 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H26FN5O2 | ||
| Mol. Mass. | 435.4939 | ||
| SMILES | OC(=O)[C@H]1C2CCC(CC2)[C@@H]1Nc1nc(nc2CCCCc12)-c1c[nH]c2ncc(F)cc12 |r,wU:3.2,wD:10.12,(65.82,-17.63,;67.15,-18.4,;68.49,-17.61,;67.17,-19.94,;68.52,-20.71,;68.53,-22.26,;67.19,-23.04,;65.85,-22.28,;66.62,-20.99,;67.74,-21.89,;65.85,-20.73,;64.51,-19.98,;63.2,-20.76,;63.67,-22.21,;62.65,-23.35,;61.15,-23.05,;60.67,-21.59,;59.17,-21.29,;58.69,-19.82,;59.71,-18.68,;61.22,-18.99,;61.7,-20.44,;63.14,-24.8,;62.24,-26.06,;63.15,-27.31,;64.62,-26.82,;65.96,-27.6,;67.3,-26.82,;67.29,-25.27,;68.63,-24.49,;65.96,-24.5,;64.61,-25.28,)| | ||
| Structure | 
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