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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Polymerase basic protein 2 | ||
| Ligand | BDBM50507239 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1829449 (CHEMBL4329323) | ||
| EC50 | 5.5±n/a nM | ||
| Citation |  Xiong, J; Wang, J; Hu, G; Zhao, W; Li, J Design, synthesis and biological evaluation of novel, orally bioavailable pyrimidine-fused heterocycles as influenza PB2 inhibitors. Eur J Med Chem162:249-265 (2019) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Polymerase basic protein 2 | |||
| Name: | Polymerase basic protein 2 | ||
| Synonyms: | PB2 | PB2_I34A1 | Polymerase basic protein 2 | RNA-directed RNA polymerase subunit P3 | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 86120.80 | ||
| Organism: | Influenza A virus (strain A/Puerto Rico/8/1934 H1N1) | ||
| Description: | ChEMBL_109460 | ||
| Residue: | 759 | ||
| Sequence: |
| ||
| BDBM50507239 | |||
| n/a | |||
| Name | BDBM50507239 | ||
| Synonyms: | CHEMBL4469921 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H24FN5O2 | ||
| Mol. Mass. | 421.4674 | ||
| SMILES | OC(=O)[C@H]1C2CCC(CC2)[C@@H]1Nc1nc(nc2CCCc12)-c1c[nH]c2ncc(F)cc12 |r,wU:3.2,wD:10.12,(39.68,-30.75,;41.02,-31.51,;42.35,-30.73,;41.03,-33.05,;42.38,-33.82,;42.39,-35.37,;41.05,-36.15,;39.72,-35.39,;40.48,-34.1,;41.6,-35,;39.71,-33.84,;38.38,-33.09,;37.07,-33.86,;37.54,-35.31,;36.52,-36.45,;35.02,-36.15,;34.54,-34.7,;33.13,-34.07,;33.29,-32.54,;34.8,-32.22,;35.57,-33.55,;37.01,-37.9,;36.11,-39.16,;37.02,-40.41,;38.48,-39.92,;39.82,-40.69,;41.16,-39.92,;41.15,-38.37,;42.49,-37.59,;39.82,-37.6,;38.48,-38.38,)| | ||
| Structure | 
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