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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Polymerase basic protein 2 | ||
| Ligand | BDBM50507240 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1829449 (CHEMBL4329323) | ||
| EC50 | 5.3±n/a nM | ||
| Citation |  Xiong, J; Wang, J; Hu, G; Zhao, W; Li, J Design, synthesis and biological evaluation of novel, orally bioavailable pyrimidine-fused heterocycles as influenza PB2 inhibitors. Eur J Med Chem162:249-265 (2019) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Polymerase basic protein 2 | |||
| Name: | Polymerase basic protein 2 | ||
| Synonyms: | PB2 | PB2_I34A1 | Polymerase basic protein 2 | RNA-directed RNA polymerase subunit P3 | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 86120.80 | ||
| Organism: | Influenza A virus (strain A/Puerto Rico/8/1934 H1N1) | ||
| Description: | ChEMBL_109460 | ||
| Residue: | 759 | ||
| Sequence: |
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| BDBM50507240 | |||
| n/a | |||
| Name | BDBM50507240 | ||
| Synonyms: | CHEMBL4468219 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H20FN5O3 | ||
| Mol. Mass. | 421.4243 | ||
| SMILES | OC(=O)[C@H]1C2CCC(CC2)[C@@H]1Nc1nc(nc2ccoc12)-c1c[nH]c2ncc(F)cc12 |r,wU:3.2,wD:10.12,(79.05,-17.09,;80.38,-17.85,;81.72,-17.07,;80.4,-19.4,;81.74,-20.17,;81.75,-21.71,;80.42,-22.49,;79.09,-21.73,;79.85,-20.44,;80.97,-21.34,;79.08,-20.18,;77.75,-19.43,;76.43,-20.21,;76.91,-21.66,;75.89,-22.79,;74.39,-22.5,;73.9,-21.04,;72.5,-20.41,;72.66,-18.88,;74.17,-18.56,;74.94,-19.9,;76.38,-24.25,;75.47,-25.5,;76.39,-26.75,;77.85,-26.26,;79.19,-27.04,;80.53,-26.26,;80.52,-24.71,;81.86,-23.93,;79.19,-23.94,;77.85,-24.72,)| | ||
| Structure | 
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