Reaction Details |
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Target | Thromboxane A2 receptor |
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Ligand | BDBM50060448 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_207644 (CHEMBL811626) |
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IC50 | 1200±n/a nM |
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Citation | Tsuri, T; Honma, T; Hiramatsu, Y; Okada, T; Hashizume, H; Mitsumori, S; Inagaki, M; Arimura, A; Yasui, K; Asanuma, F; Kishino, J; Ohtani, M Bicyclo[2.2.1]heptane and 6,6-dimethylbicyclo[3.1.1]heptane derivatives: orally active, potent, and selective prostaglandin D2 receptor antagonists. J Med Chem40:3504-7 (1997) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Thromboxane A2 receptor |
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Name: | Thromboxane A2 receptor |
Synonyms: | Prostanoid TP receptor | TA2R_HUMAN | TBXA2R | TXA2-R | Thromboxane | Thromboxane A2 receptor | Thromboxane Beta |
Type: | Enyzme |
Mol. Mass.: | 37445.28 |
Organism: | Homo sapiens (Human) |
Description: | P21731 |
Residue: | 343 |
Sequence: | MWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQGGSHTR
SSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGCRLCRFMGVVMIFFGLSPL
LLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALALGLLPLLGVGRYTVQYPG
SWCFLTLGAESGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGQEAAQQRPRDSE
VEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLRVATWN
QILDPWVYILFRRAVLRRLQPRLSTRPRSLSLQPQLTQRSGLQ
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BDBM50060448 |
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n/a |
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Name | BDBM50060448 |
Synonyms: | (+) 7-[3-(2-Phenyl-1H-indole-6-sulfonylamino)-bicyclo[2.2.1]hept-2-yl]-hept-5-enoic acid | (Z)-7-[(1S,2R,3R,4R)-3-(2-Phenyl-1H-indole-6-sulfonylamino)-bicyclo[2.2.1]hept-2-yl]-hept-5-enoic acid | CHEMBL312697 |
Type | Small organic molecule |
Emp. Form. | C28H32N2O4S |
Mol. Mass. | 492.63 |
SMILES | OC(=O)CCC\C=C/C[C@@H]1[C@H]2CC[C@H](C2)[C@H]1NS(=O)(=O)c1ccc2cc([nH]c2c1)-c1ccccc1 |
Structure |
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