| Reaction Details |
|---|
 | Report a problem with these data |
| Target | DNA ligase 1 |
|---|
| Ligand | BDBM50431467 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1837506 (CHEMBL4337639) |
|---|
| IC50 | 1000±n/a nM |
|---|
| Citation |  Saquib, M; Ansari, MI; Johnson, CR; Khatoon, S; Kamil Hussain, M; Coop, A Recent advances in the targeting of human DNA ligase I as a potential new strategy for cancer treatment. Eur J Med Chem182:0 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| DNA ligase 1 |
|---|
| Name: | DNA ligase 1 |
|---|
| Synonyms: | ATP-dependent DNA ligase | DNA Ligase I | DNLI1_HUMAN | Fatty Acid Amide Hydrolase | LIG1 | Polydeoxyribonucleotide synthase [ATP] |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 101721.76 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 919 |
|---|
| Sequence: | MQRSIMSFFHPKKEGKAKKPEKEASNSSRETEPPPKAALKEWNGVVSESDSPVKRPGRKA
ARVLGSEGEEEDEALSPAKGQKPALDCSQVSPPRPATSPENNASLSDTSPMDSSPSGIPK
RRTARKQLPKRTIQEVLEEQSEDEDREAKRKKEEEEEETPKESLTEAEVATEKEGEDGDQ
PTTPPKPLKTSKAETPTESVSEPEVATKQELQEEEEQTKPPRRAPKTLSSFFTPRKPAVK
KEVKEEEPGAPGKEGAAEGPLDPSGYNPAKNNYHPVEDACWKPGQKVPYLAVARTFEKIE
EVSARLRMVETLSNLLRSVVALSPPDLLPVLYLSLNHLGPPQQGLELGVGDGVLLKAVAQ
ATGRQLESVRAEAAEKGDVGLVAENSRSTQRLMLPPPPLTASGVFSKFRDIARLTGSAST
AKKIDIIKGLFVACRHSEARFIARSLSGRLRLGLAEQSVLAALSQAVSLTPPGQEFPPAM
VDAGKGKTAEARKTWLEEQGMILKQTFCEVPDLDRIIPVLLEHGLERLPEHCKLSPGIPL
KPMLAHPTRGISEVLKRFEEAAFTCEYKYDGQRAQIHALEGGEVKIFSRNQEDNTGKYPD
IISRIPKIKLPSVTSFILDTEAVAWDREKKQIQPFQVLTTRKRKEVDASEIQVQVCLYAF
DLIYLNGESLVREPLSRRRQLLRENFVETEGEFVFATSLDTKDIEQIAEFLEQSVKDSCE
GLMVKTLDVDATYEIAKRSHNWLKLKKDYLDGVGDTLDLVVIGAYLGRGKRAGRYGGFLL
ASYDEDSEELQAICKLGTGFSDEELEEHHQSLKALVLPSPRPYVRIDGAVIPDHWLDPSA
VWEVKCADLSLSPIYPAARGLVDSDKGISLRFPRFIRVREDKQPEQATTSAQVACLYRKQ
SQIQNQQGEDSGSDPEDTY
|
|
|
|---|
| BDBM50431467 |
|---|
| n/a |
|---|
| Name | BDBM50431467 |
|---|
| Synonyms: | CHEMBL2348305 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H15I2NO3 |
|---|
| Mol. Mass. | 511.0934 |
|---|
| SMILES | N[C@H](CO)Cc1cc(I)c(Oc2ccc(O)cc2)c(I)c1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
