| Reaction Details |
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 | Report a problem with these data |
| Target | DNA ligase 4 |
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| Ligand | BDBM50509110 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1837482 (CHEMBL4337615) |
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| IC50 | 5000±n/a nM |
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| Citation |  Saquib, M; Ansari, MI; Johnson, CR; Khatoon, S; Kamil Hussain, M; Coop, A Recent advances in the targeting of human DNA ligase I as a potential new strategy for cancer treatment. Eur J Med Chem182:0 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA ligase 4 |
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| Name: | DNA ligase 4 |
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| Synonyms: | 6.5.1.1 | DNA ligase 4 | DNA ligase IV | DNLI4_HUMAN | LIG4 | Polydeoxyribonucleotide synthase [ATP] 4 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 103988.77 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_119312 |
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| Residue: | 911 |
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| Sequence: | MAASQTSQTVASHVPFADLCSTLERIQKSKGRAEKIRHFREFLDSWRKFHDALHKNHKDV
TDSFYPAMRLILPQLERERMAYGIKETMLAKLYIELLNLPRDGKDALKLLNYRTPTGTHG
DAGDFAMIAYFVLKPRCLQKGSLTIQQVNDLLDSIASNNSAKRKDLIKKSLLQLITQSSA
LEQKWLIRMIIKDLKLGVSQQTIFSVFHNDAAELHNVTTDLEKVCRQLHDPSVGLSDISI
TLFSAFKPMLAAIADIEHIEKDMKHQSFYIETKLDGERMQMHKDGDVYKYFSRNGYNYTD
QFGASPTEGSLTPFIHNAFKADIQICILDGEMMAYNPNTQTFMQKGTKFDIKRMVEDSDL
QTCYCVFDVLMVNNKKLGHETLRKRYEILSSIFTPIPGRIEIVQKTQAHTKNEVIDALNE
AIDKREEGIMVKQPLSIYKPDKRGEGWLKIKPEYVSGLMDELDILIVGGYWGKGSRGGMM
SHFLCAVAEKPPPGEKPSVFHTLSRVGSGCTMKELYDLGLKLAKYWKPFHRKAPPSSILC
GTEKPEVYIEPCNSVIVQIKAAEIVPSDMYKTGCTLRFPRIEKIRDDKEWHECMTLDDLE
QLRGKASGKLASKHLYIGGDDEPQEKKRKAAPKMKKVIGIIEHLKAPNLTNVNKISNIFE
DVEFCVMSGTDSQPKPDLENRIAEFGGYIVQNPGPDTYCVIAGSENIRVKNIILSNKHDV
VKPAWLLECFKTKSFVPWQPRFMIHMCPSTKEHFAREYDCYGDSYFIDTDLNQLKEVFSG
IKNSNEQTPEEMASLIADLEYRYSWDCSPLSMFRRHTVYLDSYAVINDLSTKNEGTRLAI
KALELRFHGAKVVSCLAEGVSHVIIGEDHSRVADFKAFRRTFKRKFKILKESWVTDSIDK
CELQEENQYLI
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| BDBM50509110 |
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| n/a |
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| Name | BDBM50509110 |
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| Synonyms: | CHEMBL4458668 |
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| Type | Small organic molecule |
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| Emp. Form. | C11H10N4OS |
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| Mol. Mass. | 246.288 |
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| SMILES | Nc1nc(S)nc(O)c1\N=C\c1ccccc1 |
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| Structure | 
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