| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histone-lysine N-methyltransferase SMYD3 |
|---|
| Ligand | BDBM50509586 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1838818 (CHEMBL4338951) |
|---|
| EC50 | 373±n/a nM |
|---|
| Citation |  Su, DS; Qu, J; Schulz, M; Blackledge, CW; Yu, H; Zeng, J; Burgess, J; Reif, A; Stern, M; Nagarajan, R; Pappalardi, MB; Wong, K; Graves, AP; Bonnette, W; Wang, L; Elkins, P; Knapp-Reed, B; Carson, JD; McHugh, C; Mohammad, H; Kruger, R; Luengo, J; Heerding, DA; Creasy, CL Discovery of Isoxazole Amides as Potent and Selective SMYD3 Inhibitors. ACS Med Chem Lett11:133-140 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Histone-lysine N-methyltransferase SMYD3 |
|---|
| Name: | Histone-lysine N-methyltransferase SMYD3 |
|---|
| Synonyms: | SET and MYND domain-containing protein 3 | SMYD3 | SMYD3_HUMAN | ZMYND1 | ZNFN3A1 | Zinc finger MYND domain-containing protein 1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 49101.22 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9H7B4-2 |
|---|
| Residue: | 428 |
|---|
| Sequence: | MEPLKVEKFATAKRGNGLRAVTPLRPGELLFRSDPLAYTVCKGSRGVVCDRCLLGKEKLM
RCSQCRVAKYCSAKCQKKAWPDHKRECKCLKSCKPRYPPDSVRLLGRVVFKLMDGAPSES
EKLYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQDASQLPPAFDLFEAFAKVIC
NSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYL
DMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHW
KWEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRI
FFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEE
CDANIRAS
|
|
|
|---|
| BDBM50509586 |
|---|
| n/a |
|---|
| Name | BDBM50509586 |
|---|
| Synonyms: | CHEMBL4536672 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H30N4O4S |
|---|
| Mol. Mass. | 458.574 |
|---|
| SMILES | O=C(NC1CCN(CC1)S(=O)(=O)c1ccc(CN2CCCC2)cc1)c1cc(on1)C1CC1 |
|---|
| Structure | 
|
|---|
Search and Browse
