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TargetProstaglandin G/H synthase 1
LigandBDBM50063793
Substrate/Competitorn/a
Meas. Tech.ChEMBL_158940 (CHEMBL767828)
IC50 400±n/a nM
Citation Janusz, JMYoung, PAScherz, MWEnzweiler, KWu, LIGan, LPikul, SMcDow-Dunham, KLJohnson, CRSenanayake, CBKellstein, DEGreen, SATulich, JLRosario-Jansen, TMagrisso, IJWehmeyer, KRKuhlenbeck, DLEichhold, THDobson, RL New cyclooxygenase-2/5-lipoxygenase inhibitors. 2. 7-tert-butyl-2,3-dihydro-3,3-dimethylbenzofuran derivatives as gastrointestinal safe antiinflammatory and analgesic agents: variations of the dihydrobenzofuran ring. J Med Chem41:1124-37 (1998) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Prostaglandin G/H synthase 1
Name:Prostaglandin G/H synthase 1
Synonyms:COX-1 | COX1 | Cyclooxygenase | Cyclooxygenase-1 | Cyclooxygenase-1 (COX-1) | PGH1_HUMAN | PTGS1 | Prostaglandin G/H synthase (cyclooxygenase)
Type:Enzyme
Mol. Mass.:68692.62
Organism:Homo sapiens (Human)
Description:P23219
Residue:599
Sequence:
MSRSLLLWFLLFLLLLPPLPVLLADPGAPTPVNPCCYYPCQHQGICVRFGLDRYQCDCTR
TGYSGPNCTIPGLWTWLRNSLRPSPSFTHFLLTHGRWFWEFVNATFIREMLMRLVLTVRS
NLIPSPPTYNSAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDAQLLARRF
LLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQ
YQLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLY
ATLWLREHNRVCDLLKAEHPTWGDEQLFQTTRLILIGETIKIVIEEYVQQLSGYFLQLKF
DPELLFGVQFQYRNRIAMEFNHLYHWHPLMPDSFKVGSQEYSYEQFLFNTSMLVDYGVEA
LVDAFSRQIAGRIGGGRNMDHHILHVAVDVIRESREMRLQPFNEYRKRFGMKPYTSFQEL
VGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNPICS
PEYWKPSTFGGEVGFNIVKTATLKKLVCLNTKTCPYVSFRVPDASQDDGPAVERPSTEL
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  Blast E-value cutoff:
BDBM50063793
n/a
NameBDBM50063793
Synonyms:1-(8-tert-Butyl-4,4-dimethyl-thiochroman-6-yl)-pentan-1-one | CHEMBL276800
TypeSmall organic molecule
Emp. Form.C20H30OS
Mol. Mass.318.517
SMILESCCCCC(=O)c1cc(c2SCCC(C)(C)c2c1)C(C)(C)C
Structure
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