| Reaction Details |
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 | Report a problem with these data |
| Target | Acid-sensing ion channel 1 |
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| Ligand | BDBM50510046 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1839999 (CHEMBL4340214) |
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| IC50 | >30000±n/a nM |
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| Citation |  Bencheva, LI; De Matteo, M; Ferrante, L; Ferrara, M; Prandi, A; Randazzo, P; Ronzoni, S; Sinisi, R; Seneci, P; Summa, V; Gallo, M; Veneziano, M; Cellucci, A; Mazzocchi, N; Menegon, A; Di Fabio, R Identification of Isoform 2 Acid-Sensing Ion Channel Inhibitors as Tool Compounds for Target Validation Studies in CNS. ACS Med Chem Lett10:627-632 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Acid-sensing ion channel 1 |
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| Name: | Acid-sensing ion channel 1 |
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| Synonyms: | ASIC1_MOUSE | Accn2 | Acid-sensing ion channel | Acid-sensing ion channel 1 | Amiloride-sensitive cation channel 2, neuronal | Asic | Asic1 | Bnac2 | Brain sodium channel 2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 59657.36 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_119368 |
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| Residue: | 526 |
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| Sequence: | MELKTEEEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCV
CTERVQYYFCYHHVTKLDEVAASQLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALLNN
RYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDRAGHDIRDMLLSCHFRGEACS
AEDFKVVFTRYGKCYTFNSGQDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETS
FEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVSCQEQRLIYLPSPWGTCNAVTMDSDFF
DSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKDQEYCV
CEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETIEQ
KKAYEIAGLLGDIGGQMGLFIGASILTVLELFDYAYEVIKHRLCRRGKCQKEAKRNSADK
GVALSLDDVKRHNPCESLRGHPAGMTYAANILPHHPARGTFEDFTC
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| BDBM50510046 |
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| n/a |
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| Name | BDBM50510046 |
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| Synonyms: | CHEMBL4440380 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H18FN3 |
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| Mol. Mass. | 307.3647 |
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| SMILES | Cc1nn(c(C)c1-c1ccc(F)cc1)-c1ccc2CCNc2c1 |
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| Structure | 
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