| Reaction Details |
|---|
 | Report a problem with these data |
| Target | P2X purinoceptor 7 |
|---|
| Ligand | BDBM50510524 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1841592 (CHEMBL4341891) |
|---|
| IC50 | 2000±n/a nM |
|---|
| Citation |  Xiao, Y; Karra, S; Goutopoulos, A; Morse, NT; Zhang, S; Dhanabal, M; Tian, H; Seenisamy, J; Jayadevan, J; Caldwell, R; Potnick, J; Bleich, M; Chekler, E; Sherer, B; Sriraman, V Synthesis and SAR development of quinoline analogs as novel P2X7 receptor antagonists. Bioorg Med Chem Lett29:1660-1664 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| P2X purinoceptor 7 |
|---|
| Name: | P2X purinoceptor 7 |
|---|
| Synonyms: | P2RX7_MOUSE | P2rx7 | P2x7 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 68405.16 |
|---|
| Organism: | Mus musculus |
|---|
| Description: | ChEMBL_1473824 |
|---|
| Residue: | 595 |
|---|
| Sequence: | MPACCSWNDVLQYETNKVTRIQSTNYGTVKWVLHMIVFSYISFALVSDKLYQRKEPVISS
VHTKVKGIAEVTENVTEGGVTKLGHSIFDTADYTFPLQGNSFFVMTNYVKSEGQVQTLCP
EYPRRGAQCSSDRRCKKGWMDPQSKGIQTGRCVPYDKTRKTCEVSAWCPTEEEKEAPRPA
LLRSAENFTVLIKNNIHFPGHNYTTRNILPTMNGSCTFHKTWDPQCSIFRLGDIFQEAGE
NFTEVAVQGGIMGIEIYWDCNLDSWSHHCRPRYSFRRLDDKNTDESFVPGYNFRYAKYYK
ENNVEKRTLIKAFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLATVCIDLLINTYSS
AFCRSGVYPYCKCCEPCTVNEYYYRKKCESIMEPKPTLKYVSFVDEPHIRMVDQQLLGKS
LQVVKGQEVPRPQMDFSDLSRLSLSLHDSPLTPGQSEEIQLLHEEVAPKSGDSPSWCQCG
NCLPSRLPEQRRALEELCCRRKPGRCITTSKLFHKLVLSRDTLQLLLLYQDPLLVLGEEA
TNSRLRHRAYRCYATWRFGSQDMADFAILPSCCRWRIRKEFPKTEGQYSGFKYPY
|
|
|
|---|
| BDBM50510524 |
|---|
| n/a |
|---|
| Name | BDBM50510524 |
|---|
| Synonyms: | CHEMBL4525220 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H23ClF3N3O |
|---|
| Mol. Mass. | 425.875 |
|---|
| SMILES | F[C@@H]1CCN(C1)c1ccc2c(C(=O)NCC3CCCC(F)(F)C3)c(Cl)ccc2n1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
