| Reaction Details |
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 | Report a problem with these data |
| Target | Arginase |
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| Ligand | BDBM50510706 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1842051 (CHEMBL4342350) |
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| IC50 | 16500±n/a nM |
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| Citation |  Feitosa, LM; da Silva, ER; Hoelz, LVB; Souza, DL; Come, JAASS; Cardoso-Santos, C; Batista, MM; Soeiro, MNC; Boechat, N; Pinheiro, LCS New pyrazolopyrimidine derivatives as Leishmania amazonensis arginase inhibitors. Bioorg Med Chem27:3061-3069 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Arginase |
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| Name: | Arginase |
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| Synonyms: | n/a |
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| Type: | PROTEIN |
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| Mol. Mass.: | 36149.67 |
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| Organism: | Leishmania amazonensis |
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| Description: | ChEMBL_107995 |
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| Residue: | 329 |
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| Sequence: | MEHVQQYKFYKEKKMSIVLAPFSGGQPHSGVELGPDYLLKQGLQQDMEKLGWDTRLERVF
DGKVVEARKASDNGDRIGRVKRPRLTAECTEKIYKCVRRVAEQGRFPLTIGGDHSIALGT
VAGVLSVHPDAGVIWVDAHADINTMSGTVSGNLHGCPLSILLGLDRENIPECFSWVPQVL
KPNKIAYIGLRAVDDEEKKILHDLNIAAFSMHHVDRYGIDKVVSMAIEAVSPKGTEPVMV
SYDVDTIDPLYVPATGTPVRGGLSFREALFLCERIAECGRLVALDVVECNPLLAATESHV
NDTISDGRAIARCMMGETLLYTPHTSSKL
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| BDBM50510706 |
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| n/a |
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| Name | BDBM50510706 |
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| Synonyms: | CHEMBL4515068 |
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| Type | Small organic molecule |
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| Emp. Form. | C8H8F3N7S |
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| Mol. Mass. | 291.256 |
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| SMILES | Cc1cc(NNC(N)=S)n2nc(nc2n1)C(F)(F)F |
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| Structure | 
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