| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Ketohexokinase |
|---|
| Ligand | BDBM50241205 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1843861 (CHEMBL4344288) |
|---|
| IC50 | 319000±n/a nM |
|---|
| Citation |  Romero, FA; Jones, CT; Xu, Y; Fenaux, M; Halcomb, RL The Race to Bash NASH: Emerging Targets and Drug Development in a Complex Liver Disease. J Med Chem63:5031-5073 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Ketohexokinase |
|---|
| Name: | Ketohexokinase |
|---|
| Synonyms: | Hepatic fructokinase | KHK | KHK_HUMAN | Ketohexokinase | Ketohexokinase (KHK) | Ketohexokinase (KHK) Isoform C |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 32521.64 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 298 |
|---|
| Sequence: | MEEKQILCVGLVVLDVISLVDKYPKEDSEIRCLSQRWQRGGNASNSCTVLSLLGAPCAFM
GSMAPGHVADFLVADFRRRGVDVSQVAWQSKGDTPSSCCIINNSNGNRTIVLHDTSLPDV
SATDFEKVDLTQFKWIHIEGRNASEQVKMLQRIDAHNTRQPPEQKIRVSVEVEKPREELF
QLFGYGDVVFVSKDVAKHLGFQSAEEALRGLYGRVRKGAVLVCAWAEEGADALGPDGKLL
HSDAFPPPRVVDTLGAGDTFNASVIFSLSQGRSVQEALRFGCQVAGKKCGLQGFDGIV
|
|
|
|---|
| BDBM50241205 |
|---|
| n/a |
|---|
| Name | BDBM50241205 |
|---|
| Synonyms: | CHEMBL1463512 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C9H5F3N2O |
|---|
| Mol. Mass. | 214.144 |
|---|
| SMILES | Oc1nc2ccccc2nc1C(F)(F)F |
|---|
| Structure | 
|
|---|
Search and Browse
