| Reaction Details |
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 | Report a problem with these data |
| Target | Ketohexokinase |
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| Ligand | BDBM319585 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1843861 (CHEMBL4344288) |
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| IC50 | 14±n/a nM |
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| Citation |  Romero, FA; Jones, CT; Xu, Y; Fenaux, M; Halcomb, RL The Race to Bash NASH: Emerging Targets and Drug Development in a Complex Liver Disease. J Med Chem63:5031-5073 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Ketohexokinase |
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| Name: | Ketohexokinase |
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| Synonyms: | Hepatic fructokinase | KHK | KHK_HUMAN | Ketohexokinase | Ketohexokinase (KHK) | Ketohexokinase (KHK) Isoform C |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 32521.64 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 298 |
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| Sequence: | MEEKQILCVGLVVLDVISLVDKYPKEDSEIRCLSQRWQRGGNASNSCTVLSLLGAPCAFM
GSMAPGHVADFLVADFRRRGVDVSQVAWQSKGDTPSSCCIINNSNGNRTIVLHDTSLPDV
SATDFEKVDLTQFKWIHIEGRNASEQVKMLQRIDAHNTRQPPEQKIRVSVEVEKPREELF
QLFGYGDVVFVSKDVAKHLGFQSAEEALRGLYGRVRKGAVLVCAWAEEGADALGPDGKLL
HSDAFPPPRVVDTLGAGDTFNASVIFSLSQGRSVQEALRFGCQVAGKKCGLQGFDGIV
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| BDBM319585 |
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| n/a |
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| Name | BDBM319585 |
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| Synonyms: | US10174007, Example 4 | US10787438, Example 4 | US10988463, Example 4 | US11634410, Example 4 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H19F3N4O2 |
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| Mol. Mass. | 356.3429 |
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| SMILES | C[C@H]1CCN1c1nc(cc(n1)C(F)(F)F)N1C[C@H]2[C@H](CC(O)=O)[C@H]2C1 |r| |
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| Structure | 
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