| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-glucuronidase |
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| Ligand | BDBM50511220 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1844168 (CHEMBL4344595) |
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| Ki | 132±n/a nM |
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| Citation |  Dashnyam, P; Lin, HY; Chen, CY; Gao, S; Yeh, LF; Hsieh, WC; Tu, Z; Lin, CH Substituent Position of Iminocyclitols Determines the Potency and Selectivity for Gut Microbial Xenobiotic-Reactivating Enzymes. J Med Chem63:4617-4627 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-glucuronidase |
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| Name: | Beta-glucuronidase |
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| Synonyms: | Beta-glucuronidase | Beta-glucuronidase (β-glucuronidase) | EMBL:AAI33416.1 | Ensembl:ENSBTAP00000000941 | Ensembl:ENSBTAP00000000941} | GUSB |
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| Type: | Protein |
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| Mol. Mass.: | 74467.69 |
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| Organism: | Bos taurus (Bovine) |
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| Description: | EC 3.2.1.31, bovine liver |
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| Residue: | 652 |
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| Sequence: | MLRGSAGAWAVLGPLLWGCGLSLLQGGMLYPRESRSRERKELDGLWSFRADFSDNRRQGF
EQQWYRAPLRESGPTLDMPVPSSFNDVGQDGQLRSFVGWVWYEREITLPQRWTEDLGTRV
VLRIGSAHYYAIVWVNGVHVLEHEGGHLPFEADISKLVQSGPLSSCRITIAINNTLSPHT
LPPGTILYKTDPSMYPKGYFVQNTKFDFFNYAGLHRSVLLYTTPTTYIDDITVTTDMDQD
IGLVNYQIIVQGSDHFQVDVSLLDEEGKVMAKGAGAEGQLQVPSAHLWWPYLMHEHPAYL
YSLEVKLTAQTAVGPVSDFYTLPVGIRTVAVTKSQFLINGKPFYFRGVNKHEDADIRGKG
FDWPLLVKDFNLLRWLGANAFRTSHYPYSEEVLQLCDRYGIVVIDESPGVGIVLVESFSN
VSLQHHLEVMEEMIRRDKNHPAVVMWSLANEPASFLKPAGYYFKTLIAHTKALDPSRPVT
FVTNTNYEADLGAPYVDIICVNSYYSWYHDYGHMEVIQLQLATQFENWYKAYQKPMIQSE
YGADAIEGFHEDPPLMFSEEYQKGLLQQYHVVLDQKRKEYVVGELIWNFADFMTNQSPVR
MIGNRKGIFTRQRQPKSAAFLLRERYWKLANETRYQRSAVTSQCVGSGLFTV
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| BDBM50511220 |
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| n/a |
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| Name | BDBM50511220 |
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| Synonyms: | CHEMBL1232598 |
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| Type | Small organic molecule |
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| Emp. Form. | C6H9NO6 |
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| Mol. Mass. | 191.1388 |
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| SMILES | O[C@H]1[C@H](O)[C@H](NC(=O)[C@@H]1O)C(O)=O |r| |
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| Structure | 
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