| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 2 |
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| Ligand | BDBM50511248 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1844236 (CHEMBL4344663) |
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| IC50 | 352±n/a nM |
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| Citation |  Pan, Z; Li, X; Wang, Y; Jiang, Q; Jiang, L; Zhang, M; Zhang, N; Wu, F; Liu, B; He, G Discovery of Thieno[2,3- J Med Chem63:3678-3700 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 2 |
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| Name: | Histone deacetylase 2 |
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| Synonyms: | Cereblon/Histone deacetylase 2 | HD2 | HDAC2 | HDAC2_HUMAN | Histone deacetylase 2 (HDAC2) | Human HDAC2 |
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| Type: | Chromatin regulator; hydrolase; repressor |
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| Mol. Mass.: | 55356.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q92769 |
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| Residue: | 488 |
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| Sequence: | MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA
TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA
GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH
GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQ
IFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG
GGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYM
EKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEE
FSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGT
KSEQLSNP
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| BDBM50511248 |
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| n/a |
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| Name | BDBM50511248 |
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| Synonyms: | CHEMBL4581033 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H22N6O3S |
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| Mol. Mass. | 450.513 |
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| SMILES | Cc1noc(C)c1-c1nc2sc3CN(CC(=O)Nc4ccccc4N)CCc3c2c(=O)[nH]1 |
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| Structure | 
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